Evidence map›Paper›PMID 40204505›Full record

ArticleAllergy, asthma & immunology research2025

The Phenotypes of Asthma-Bronchiectasis Overlap: Clinical Characteristics and Outcomes.

Zhen-Hong Lin, Cui-Xia Pan, Jia-Hui He, Xiao-Xian Zhang, Sheng-Zhu Lin, Qing-Ling Zhang, Mei Dai, Wei-Quan Liang, Wei-Jie Guan

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Article in Allergy, asthma & immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhen-Hong Lin *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Cui-Xia Pan *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0003-2877-2475
Jia-Hui He *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiao-Xian Zhang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Sheng-Zhu LinState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4270-0112
Qing-Ling ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Mei DaiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wei-Quan LiangDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Foshan, Foshan, China. ribby8@126.com.
Wei-Jie GuanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-5463-391X

Funding

Foshan "14th Five-year Plan" medical training specialty construction project FSPY145014Guangzhou Medical UniversityGuangzhou National Laboratory GZNL2024A02003Guangzhou National Laboratory SRPG22-021Guangzhou Science and Technology Plans 202201020517Guangzhou Science and Technology Plans 2023B03J0407Guangzhou Science and Technology Plans 2024A03J1206Guangzhou Science and Technology Plans 2024A04J6495National Natural Science Foundation of China 82470040Outstanding Youth Science Fund Project of the National Natural Science Foundation of China 82222001
6 · The paper itself

Abstract

backgroundAsthma-bronchiectasis overlap (ABO) encompasses heterogeneous manifestations, which may predict distinct clinical outcomes. We sought to identify the clinical phenotypes of ABO and compare them to asthma alone or bronchiectasis alone.

methodsIn this retrospective cohort study, we extracted electronic medical records from 292 inpatients with ABO, 901 inpatients with asthma alone, and 1,192 inpatients with bronchiectasis alone who were hospitalized between 2015 and 2020. We phenotyped ABO using 2-step unsupervised clustering analysis by using an independent cohort (n = 76).

resultsCompared to asthma or bronchiectasis alone, ABO exhibited greater disease severity and worse clinical outcomes. We identified 3 ABO phenotypes: asthma-dominant ABO (ABO-A, n = 100) with more prominent asthma symptoms; bronchiectasis-dominant ABO (ABO-B, n = 89) with more pronounced features of bronchiectasis; and co-existence of asthma and severe bronchiectasis (ABO-S, n = 103) with worse clinical outcomes. Compared to ABO-B, both ABO-A and ABO-S were associated with significantly higher blood neutrophil ratios (55.8% vs. 59.1% vs. 64.4%,

conclusionsThe radiologic severity of bronchiectasis and the use of systemic corticosteroids can identify the clinical phenotypes of ABO. The heterogeneity of clinical manifestations may help formulate personalized management strategies and predict the prognosis of ABO.

Indexed as

AsthmaAsthma-bronchiectasis overlapbronchiectasisclinical phenotypescorticosteroidslung functionprognosistwo-step clustering

Identifiers

PMID40204505
PMCPMC11982639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.