Evidence map›Paper›PMID 40204453›Full record

ArticleJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi2025

Histamine-induced cytosolic calcium mobilization in human bronchial smooth muscle cells.

Kyung Jin Choi, Woo Young Jeon, Mee Young Lee, Se Hoon Kim, Hyung Seo Park

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Article in Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyung Jin ChoiDepartment of Physiology, College of Medicine and Myunggok Medical Research Institute, Konyang University, Daejeon 35365, Korea.
Woo Young JeonKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.
Mee Young LeeKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.
Se Hoon KimDepartment of Physiology, College of Medicine and Myunggok Medical Research Institute, Konyang University, Daejeon 35365, Korea.
Hyung Seo ParkDepartment of Physiology, College of Medicine and Myunggok Medical Research Institute, Konyang University, Daejeon 35365, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histamine is a well-known mediator of bronchoconstriction. Despite the widespread use of histamine as a tool to study the bronchial smooth muscle function, the precise mechanism by which it causes calcium mobilization in bronchial smooth muscle cells remains unclear. Therefore, the current study aimed to investigate the mechanism of action of histamine in calcium mobilization in cultured human bronchial smooth muscle cells. A series of in vitro calcium imaging experiments have shown that histamine increases intracellular calcium levels in a concentration-dependent manner. The half maximum concentration of cytosolic Ca

Indexed as

BronchiCalciumCytosolHistamineMyocytes, Smooth MuscleBronchoconstrictionCaffeineCalcium SignalingCells, CulturedChlorpheniramineEstrenesHumansInositol 1,4,5-Trisphosphate ReceptorsPyrrolidinonesType C Phospholipases1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dioneCaffeineCalciumChlorpheniramineEstrenesHistamineInositol 1,4,5-Trisphosphate ReceptorsPyrrolidinonesType C Phospholipasescytosolic calciumH1 receptorhistamineinositol 1,4,5-trisphosphate receptormitochondria

Identifiers

PMID40204453
PMCPMC11996695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.