Evidence map›Paper›PMID 40204331›Full record

ArticleBMJ open2025

Effects of intermittent theta burst stimulation (iTBS) on appetite change and body weight in inpatients with schizophrenia in China: study protocol for a randomised controlled trial.

Yue Qin, Jin Yang, Baoyan Xu, Jun Yang, Haiyu Chen, Tianxiang Zou, Ziwei Teng, Jieyu Liu, Tengteng Zhang, Yuhan Su and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05783063 (Effects of Intermittent Theta Burst Stimulation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05783063 narecruitingnot on this map

Effects of Intermittent Theta Burst Stimulation (iTBS) on Increased Appetite Induced by Antipsychotics in Patients With Schizophrenia

TypeinterventionalSponsorCentral South UniversityRan2023 to 2026Enrolled60ConditionsSchizophreniaArmsActive iTBS, Sham iTBS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yue Qin *The Second People's Hospital of Dali Bai Autonomous Prefecture, Dali, Yunnan, China.
Jin Yang *The Second People's Hospital of Dali Bai Autonomous Prefecture, Dali, Yunnan, China.
Baoyan XuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jun YangThe Second People's Hospital of Dali Bai Autonomous Prefecture, Dali, Yunnan, China.
Haiyu ChenDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Tianxiang ZouDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0009-0001-3097-5189
Ziwei TengDepartment of Psychiatry, Brain Hospital of Hunan Province, The Second People's Hospital of Hunan Province, The School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, People's Republic of China.
Jieyu LiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Tengteng ZhangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yuhan SuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Renrong WuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-5804-6648
Zaiwen DongThe Second People's Hospital of Dali Bai Autonomous Prefecture, Dali, Yunnan, China jinghuangserena@csu.edu.cn 1040305768@qq.com 79152837@qq.com.
Chong YangThe Second People's Hospital of Dali Bai Autonomous Prefecture, Dali, Yunnan, China jinghuangserena@csu.edu.cn 1040305768@qq.com 79152837@qq.com.
Jing HuangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China jinghuangserena@csu.edu.cn 1040305768@qq.com 79152837@qq.com.ORCID http://orcid.org/0000-0002-7317-7259

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAntipsychotics are likely to cause weight gain owing to increased appetite and other metabolic disturbances in patients with schizophrenia on prolonged medication. Conventional high-frequency repetitive transcranial magnetic stimulation has been employed to treat people with obesity and has shown certain effectiveness. The goal of this clinical trial is to evaluate the efficacy of intermittent theta burst stimulation (iTBS) in ameliorating appetite increase and weight gain induced by antipsychotics in patients with schizophrenia. METHODS AND ANALYSIS: In this randomised, double-blind, sham-controlled trial, 60 participants will be enrolled and allocated (1:1) to receive active or sham iTBS on the dorsolateral prefrontal cortex for 5 consecutive days. Appetite, body mass index, clinical symptoms, cognitive function and laboratory indicators will be assessed at baseline, after 5 days of treatments, and at 2 weeks and 4 weeks after all treatments. MRI examination will be conducted to detect brain structure, perfusion and functional connectivity. Data analysis will be conducted in a modified intention-to-treat population. The results of the study will provide evidence on the effectiveness and feasibility of iTBS in improving increased appetite induced by antipsychotics and explore the underlying neuroendocrine pathway affected by the intervention. The primary objective is to evaluate the efficacy of iTBS in weight gain in patients with schizophrenia taking antipsychotics. The secondary objective is to identify the neuroendocrine changes related to appetite in response to iTBS by assessing the variables of cognitive control, glucolipid metabolism and brain activity. ETHICS AND DISSEMINATION: The study protocol has been approved by the National Clinical Medical Research Center Ethics Committee of The Second People's Hospital of Dali Bai Autonomous Prefecture (no: 2023YN3) and The Second Xiangya Hospital (no: 2024K008). Written informed consent will be obtained voluntarily before enrolment. The results will be disseminated through publication in peer-reviewed journals and presentation at international conferences. TRIAL REGISTRATION NUMBER: NCT05783063.

Indexed as

Antipsychotic AgentsAppetiteBody WeightSchizophreniaTranscranial Magnetic StimulationAdultChinaDouble-Blind MethodFemaleHumansInpatientsMagnetic Resonance ImagingMaleMiddle AgedRandomized Controlled Trials as TopicWeight GainAntipsychotic AgentsMagnetic resonance imagingObesitySchizophrenia & psychotic disordersTranscranial Magnetic Stimulation

Identifiers

PMID40204331
PMCPMC11979493

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.