Evidence map›Paper›PMID 40204148›Full record

ArticleCancer letters2025

Chaperone directed heterobifunctional molecules circumvent KRAS

Ines Pulido, Qiyue Luan, Sara Pastor-Puente, Laura Gunder, Yaya Wang, Chenghao Ying, Jinhua Li, Yuetong Sun, Yan Dai, Christian Ascoli and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ines PulidoDepartment of Surgery, Division of Cardiothoracic Surgery, University of Illinois Chicago, Chicago, IL, 60612, USA; University of Illinois Hospital & Health Sciences System Cancer Center, University of Illinois Chicago, Chicago, IL, 60612, USA.
Qiyue LuanDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, 60612, USA.
Sara Pastor-PuenteDepartment of Ophthalmology and Visual Science, University of Illinois Chicago, Chicago, IL, 60612, USA.
Laura GunderDepartment of Surgery, Division of Cardiothoracic Surgery, University of Illinois Chicago, Chicago, IL, 60612, USA.
Yaya WangRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Chenghao YingRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Jinhua LiRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Yuetong SunRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Yan DaiRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Christian AscoliDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, Chicago, IL, 60612, USA.
Khaled AbdelhadyDepartment of Surgery, Division of Cardiothoracic Surgery, University of Illinois Chicago, Chicago, IL, 60612, USA.
Malek MassadDepartment of Surgery, Division of Cardiothoracic Surgery, University of Illinois Chicago, Chicago, IL, 60612, USA.
Thomas L PrinceRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Guoqiang WangRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Kevin P FoleyRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Weiwen YingRanok Therapeutics, Waltham, MA, 02451, USA; Ranok Therapeutics, Hangzhou, 310020, China.
Ian PapautskyDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, 60612, USA.
Julian CarreteroDepartment of Physiology, Universitat de Valencia, Valencia, 46100, Spain.
Takeshi ShimamuraDepartment of Surgery, Division of Cardiothoracic Surgery, University of Illinois Chicago, Chicago, IL, 60612, USA; University of Illinois Hospital & Health Sciences System Cancer Center, University of Illinois Chicago, Chicago, IL, 60612, USA. Electronic address: tshima2@uic.edu.

Funding

Investigation of CXCR7 signaling in EGFR TKI resistant NSCLCR01CA230778 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHIMAMURA, TAKESHI · 2019 to 2023
$1.9M
NCI NIH HHS R01 CA230778
6 · The paper itself

Abstract

While KRAS

Indexed as

Drug Resistance, NeoplasmHSP90 Heat-Shock ProteinsProto-Oncogene Proteins p21(ras)AnimalsCell Line, TumorHumansMiceMice, NudeMutationXenograft Model Antitumor AssaysHSP90 Heat-Shock ProteinsKRAS protein, humanProto-Oncogene Proteins p21(ras)G12CHSP90KRASNSCLCResistance

Identifiers

PMID40204148
PMCPMC13276862

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.