Evidence map›Paper›PMID 40203884›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Trpv4-mediated mechanotransduction regulates the differentiation of valvular interstitial cells to myofibroblasts: implications for aortic valve stenosis.

Pritha Mukherjee, Manisha Mahanty, Bidisha Dutta, Suneha G Rahaman, Karunakaran R Sankaran, Zhenguo Liu, Shaik O Rahaman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. A novel role for TRPV1 in macrophage giant cell formation.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Pritha MukherjeeDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, United States.
Manisha MahantyDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, United States.
Bidisha DuttaDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, United States.
Suneha G RahamanDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, United States.
Karunakaran R SankaranDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, United States.
Zhenguo LiuCenter for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri, United States.ORCID 0000-0002-9917-6684
Shaik O RahamanDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, United States.ORCID 0000-0002-6481-392X

Funding

Investigate the mechanisms underlying microRNA-146a activity in regulation of foreign body response to biomaterialsR01AI172086 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Wenquan Ou, Shaik O Rahaman · 2022 to 2026
$3.5M
Role of TRPV4 mechanotransduction in foreign body responseR01EB024556 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI RAHAMAN, SHAIK O, ZHU, XIAOPING · 2017 to 2020
$1.7M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01EB024556NIAID NIH HHS R01 AI172086NIBIB NIH HHS R01 EB024556
6 · The paper itself

Abstract

As aortic valve stenosis (AVS) progresses, the valve tissue also stiffens. This increase in tissue stiffness causes the valvular interstitial cells (VICs) to transform into myofibroblasts in response. VIC-to-myofibroblast differentiation is critically involved in the development of AVS. Herein, we investigated the role of mechanosensitive Ca

Indexed as

Aortic ValveAortic Valve StenosisCell DifferentiationMechanotransduction, CellularMyofibroblastsTRPV Cation ChannelsAnimalsCells, CulturedMaleMiceMice, Inbred C57BLMice, KnockoutTransforming Growth Factor beta1Tgfb1 protein, mouseTransforming Growth Factor beta1Trpv4 protein, mouseTRPV Cation Channelsaortic valve stenosismechanotransductiontraction force microscopytransient receptor potential vanilloid 4valvular interstitial cell

Identifiers

PMID40203884
PMCPMC12175854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.