SynthesisNeonatology2025
Comparing Malposition and Complications Associated with Ultrasound-Guided versus Radiography-Guided Central Catheter Tip-Position in Neonates: A Systematic Review and Meta-Analysis.
Synthesis in Neonatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- [Clinical practice guideline for point-of-care ultrasound-guided peripherally inserted central catheter placement in neonates (2026)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Guideline
- Devices for Neonatal Peripheral Catheterization and Tip Confirmation: A Systematic Review and Meta-Analysis.Neonatology · 2026Pooled it
- Point-of-care ultrasound for umbilical venous catheter placement and surveillance in neonates: practical guidance and governance.European journal of pediatrics · 2026Review
- Primary malposition of peripherally inserted central catheter in the inferior vena cava among neonates: a case series.Frontiers in pediatrics · 2026Article
- The Role of Bedside Ultrasonography in Neonatal Central Venous Access Applications.Sisli Etfal Hastanesi tip bulteni · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
<p>Introduction: There is a growing interest in ultrasound-guided central catheter (CC) tip-position, driven by its potential to improve accuracy and reduce complications. We aimed to systematically review and meta-analyze studies that reported complications associated with ultrasound-guided versus radiography-guided CC tip-position in neonates.
methodsWe searched Medline, Cochrane, Embase, CINAHL, and <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">clinicaltrials.gov</ext-link> for randomized controlled trials (RCTs) and non-randomized controlled studies (NRSs) comparing the complications of ultrasound- versus X-ray-guided CC tip-position in neonates up to June 2024. RCTs and NRSs were analyzed separately. The outcomes included malposition, number of X-rays, procedure time, catheter manipulation, cardiac tamponade, extravasation, occlusion, and sepsis rates. Subgroup meta-analysis based on catheter type was performed. Statistical analyses were conducted using Review Manager 5.4.1 and R 4.1.0, and the GRADE methodology was applied to assess evidence certainty.
resultsEight studies (4 RCTs and 4 NRSs, N = 1,322 neonates) were included. Ultrasound-guided catheter tip-position significantly reduced malposition rates (3 RCTs, N = 181, RR: 0.51, 95% CI: 0.37 to 0.70; 4 NRSs, N = 1,110, RR: 0.25, 95% CI: 0.11 to 0.57) and decreased the need for X-rays (2 RCTs, N = 112, MD: -1.22, 95% CI: -2.32 to -0.11; 2 NRSs, N = 401, MD: -0.31, 95% CI: -0.47 to -0.15). No significant differences were found in procedure time, catheter manipulation, or sepsis rates. All evidence was of low certainty per grade.
conclusionsThe use of ultrasound-guided CC tip-position in neonates is associated with a reduction in malposition rates and radiation exposure (low certainty evidence). Further research is needed to confirm the benefits of ultrasound-guided CC tip-position in neonates. </p>.
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