ArticleScience translational medicine2025
Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay.
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Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
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Who cites it
15 citing papers in PubMed.
- A fully integrated sample-to-answer diagnostic platform enables rapid quantification of post-transplant infection at the point-of-care.Nature communications · 2026Article
- Diagnostic accuracy of GeneReady MTB assay on sputum for detecting pulmonary tuberculosis: a prospective multicenter study in China.Journal of clinical microbiology · 2026Article
- Clinical Evaluation of a Tandem qPCR-CRISPR Assay for Multidrug-Resistant or Rifampicin-Resistant Tuberculosis: A Prospective Diagnostic Accuracy Study.Microorganisms · 2026Article
- Deep Learning-Assisted Digital Microfluidic Platform for Automated CRISPR/Cas12 Detection ofACS measurement science au · 2026Article
- Integrated Optothermal Paperfluidic Platform for Single-Step, Model-Driven CRISPR-Cas12a Diagnostics ofACS omega · 2026Article
- "Subclinical tuberculosis": a person-centred critique.ERJ open research · 2026Article
- PTBD: a machine learning-based non-invasive diagnostic model for pulmonary tuberculosis using large-scale blood transcriptomes.BMC biology · 2026Article
- Cervical lymph node TB: diagnostic yield and patient profile.IJTLD open · 2026Article
- Nuc domain electrostatics drive the trans cleavage activity of CRISPR-Cas12a.Nucleic acids research · 2026Article
- Host- and pathogen-related determinants of pulmonaryEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- From mutation detection to treatment decisions: CRISPR-enabled diagnostics for drug-resistant tuberculosis.Frontiers in bioengineering and biotechnology · 2026Review
- A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2026 Update for Clinicians and Scientists.Pathogens & immunity · 2026Review
- Exploring non-sputum biosignatures for tuberculosis triage and diagnosis in children living with HIV.Expert review of molecular diagnostics · 2025Review
- Sensitive pathogen DNA detection by a multi-guide RNA Cas12a assay favoring trans- versus cis-cleavage.Nature communications · 2025Article
- Integrated horizontal convective PCR system for clinical diagnostics.Science advances · 2025Article
Corrections and comments
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Authors and funding
21 authors.
Brady M YoungquistCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0003-3034-0594
Julian SalibaCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Yelim KimCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0009-0007-8666-050X
Thomas J CutroSchool of Science and Engineering, Tulane University, New Orleans, LA 70112, USA.ORCID 0009-0005-8535-2850
Christopher J LyonCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Juan OlivoO&M Medical School (O&Med), Santo Domingo, 10204, Dominican Republic.ORCID 0009-0003-0647-5568
Ngan HaHouston Methodist Research Institute, Houston, TX 77030, USA.
Janelle FineDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6800-4222
Rebecca ColmanDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6854-2100
Carlos VergaraO&M Medical School (O&Med), Santo Domingo, 10204, Dominican Republic.ORCID 0009-0003-8966-2552
James RobinsonSection of Pediatric Infectious Disease, Department of Pediatrics, Tulane University, New Orleans, LA 70112, USA.
Sylvia LaCourseDepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-9809-5997
Richard S GarfeinDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-3663-7153
Donald G CatanzaroDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR 72701, USA.ORCID 0000-0003-1760-0574
Christoph LangeDepartment of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, 23845, Germany.ORCID 0000-0002-9691-4741
Eddy Perez-ThenO&M Medical School (O&Med), Santo Domingo, 10204, Dominican Republic.ORCID 0000-0001-7724-0668
Edward A GravissHouston Methodist Research Institute, Houston, TX 77030, USA.ORCID 0000-0003-1024-5813
Charles D MitchellDepartment of Pediatrics, Division of Infectious Diseases and Immunology, University of Miami Miller School of Medicine, Batchelor Children's Research Institute, Miami, FL 33136, USA.ORCID 0000-0002-1607-7999
Timothy RodwellDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-2779-3197
Bo NingCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0001-9437-7244
Tony Y HuCenter for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0002-5166-4937
Funding
Direct quantitation of the circulating Mtb-peptidome for pediatric TB managementR01HD090927 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon, Charles DeBeaux Mitchell · 2017 to 2026
$4.5MMtb and HIV/SIV antigen peptide signatures as blood biomarkers to detect early infection to active disease in young children and NHPR01HD103511 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI LYON, CHRISTOPHER J · 2021 to 2025
$3.7MAn Antigen-Detection Blood Test for Pulmonary TuberculosisR01AI141500 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CATANZARO, ANTONINO, RODWELL, TIMOTHY CHARLES · 2019 to 2023
$3.6MDigital Nanoplasmonic Quantification of Tumor-derived Extracellular Vesicles in Plasma MicrosamplesU01CA252965 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y., LU, HUA · 2020 to 2024
$3.0MA nanopore biosensor for leveling Mtb antigens in bloodR01AI144168 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon · 2022 to 2026
$3.0MRapid Detection of TB from Blood using Cell-Free DNA and CRISPRR01AI174964 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard S Garfein, Timothy Charles Rodwell · 2023 to 2026
$2.9MMultiplexed detection of cell-free M. Tuberculosis DNA and its drug-resistant variants in bloodR01AI175618 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Zhen Huang, Jeffrey Tornheim · 2023 to 2026
$2.9MDiagnostic Innovations for Pediatric Tuberculosis in BoliviaR01AI173021 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI ROBERT H GILMAN, Bo Ning · 2023 to 2026
$2.8MCRISPR detection of circulating cell-free Mycobacterium avium complex (MAC) DNA for rapid diagnosis and monitoring of MAC pulmonary diseaseR01AI177986 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bo Ning, Kevin Loring Winthrop · 2024 to 2026
$2.3MCRISPR-TB for pediatric TB diagnosis and treatment responseR01AI179714 · NIAID · UNIVERSITY OF WASHINGTON · PI Sylvia LaCourse · 2024 to 2026
$2.2MQuantification of brain-derived extracellular vesicle microRNAs in blood by a liposome-mediated CRISPR assay for traumatic brain injury detectionR21NS130542 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI HU, TONY Y. · 2022 to 2022
$437kLiposome fusion enabled extracellular vesicle detection for COVID-19R21AI169582 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NING, BO · 2022 to 2023
$419kNCI NIH HHS U01 CA252965NIAID NIH HHS R01 AI141500NIAID NIH HHS R01 AI144168NIAID NIH HHS R01 AI173021NIAID NIH HHS R01 AI174964NIAID NIH HHS R01 AI175618NIAID NIH HHS R01 AI177986NIAID NIH HHS R01 AI179714NIAID NIH HHS R21 AI169582NICHD NIH HHS R01 HD090927NICHD NIH HHS R01 HD103511NINDS NIH HHS R21 NS130542
Abstract
Rapid portable assays are needed to improve diagnosis, treatment, and reduce transmission of tuberculosis (TB), but current tests are not suitable for patients in resource-limited settings with high TB burden. Here we report a low complexity, lab-in-tube system that is read by an integrated handheld device that detects
Indexed as
TuberculosisAdolescentChildChild, PreschoolDNA, BacterialHumansInfantMycobacterium tuberculosisPoint-of-Care SystemsSensitivity and SpecificitySputumDNA, Bacterial
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.