Evidence map›Paper›PMID 40203016›Full record

SynthesisPloS one2025

Plasma-lyte solution versus saline in kidney transplantation: A systematic review and meta-analysis of randomized controlled trials.

Yucai Chang, Yuechen Qin, Yue Zou, Haijian Zeng, Chunlan Li, Mengtian Qin, Jianyu Wu, Jian Ban

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yucai ChangThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.
Yuechen QinThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.
Yue ZouThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.
Haijian ZengThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.
Chunlan LiThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.
Mengtian QinThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.
Jianyu WuThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.
Jian BanThe First Affiliated Hospital of Guangxi University of Science and Technology, Guangxi University of Science and Technology, Liuzhou, Guangxi Province, China.ORCID 0009-0008-6847-2545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe optimal intravenous fluid for kidney transplantation (KT) is still controversial. This meta-analysis aimed to compare the efficacy and safety of plasma-lyte solution (PL) versus saline (NS) in kidney transplantation. MATERIALS AND

methodsA comprehensive search was conducted across four databases (PubMed, Embase, Web of Science, and the Cochrane Library) to identify relevant randomized controlled trials (RCTs) comparing plasma-lyte and saline in kidney transplantation. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Meta-analyses of delayed graft function (DGF), creatinine levels, urine output, blood pH, bicarbonate, base excess, electrolytes, serum chloride, potassium and sodium immediately post-surgery were performed.

resultsTotally six randomized controlled studies with 1197 patients were included. In comparison to the NS group, the PL group exhibited a significantly lower incidence of DGF (OR: 0.66, 95% CI: 0.51 to 0.86, P =  0.002) and reduced serum chloride (MD: -8.87, 95% CI: -13.50 to -4.25, P = 0.0002) as well as serum sodium(MD: -1.08, 95% CI: -1.54 to -0.61, P <  0.00001), while blood pH(MD: 0.05, 95% CI: 0.03 to 0.07, P <  0.00001), bicarbonate (MD: 2.09, 95% CI: 1.21 to 2.97, P = 0.005), and base excess levels (MD: 2.42, 95% CI: 0.72 to 4.11, P <  0.00001) were significantly elevated. No statistically significant differences were observed in creatinine, urine output, or potassium concentrations between two groups.

conclusionsThis meta-analysis compared the efficacy and safety between plasma-lyte and saline in kidney transplantation. Plasma-lyte reduced delayed graft function in kidney transplant compared to saline.

trial registrationPROSPERO (CRD42024588701).

Indexed as

Kidney TransplantationPotassium ChlorideSaline SolutionSodium AcetateSodium ChlorideDelayed Graft FunctionGluconatesHumansMagnesium ChlorideRandomized Controlled Trials as TopicGluconatesMagnesium ChloridePlasma-lyte 148Potassium ChlorideSaline SolutionSodium AcetateSodium Chloride

Identifiers

PMID40203016
PMCPMC11981191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.