Evidence map›Paper›PMID 40202982›Full record

ArticlePloS one2025

Study protocol for the EYEdentify project: An examination of gaze behaviour in autistic adults using a virtual reality-based paradigm.

Alberte Cathrine Ehrhardt Jeppesen, Johannes Andresen, Rizwan Parvaiz, Lars Clemmensen, Jens Richardt Møllegaard Jepsen, Dan Witzner Hansen, Louise Birkedal Glenthøj

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alberte Cathrine Ehrhardt JeppesenVIRTU Research Group, Copenhagen Research Centre for Mental Health (CORE), Copenhagen University Hospital - Mental Health Services Capital Region, Copenhagen, Denmark.ORCID 0009-0004-9918-6606
Johannes AndresenVIRTU Research Group, Copenhagen Research Centre for Mental Health (CORE), Copenhagen University Hospital - Mental Health Services Capital Region, Copenhagen, Denmark.ORCID 0009-0006-0529-0571
Rizwan ParvaizDepartment of ADHD and Autism, Mental Health Services Capital Region, Copenhagen, Denmark.
Lars ClemmensenVIRTU Research Group, Copenhagen Research Centre for Mental Health (CORE), Copenhagen University Hospital - Mental Health Services Capital Region, Copenhagen, Denmark.
Jens Richardt Møllegaard JepsenCopenhagen Research Centre for Mental Health (CORE), Copenhagen University Hospital - Mental Health Services Capital Region, Copenhagen, Denmark.
Dan Witzner HansenMachine Learning Group, Data Science Section, IT University of Copenhagen, Copenhagen, Denmark.
Louise Birkedal GlenthøjVIRTU Research Group, Copenhagen Research Centre for Mental Health (CORE), Copenhagen University Hospital - Mental Health Services Capital Region, Copenhagen, Denmark.ORCID 0000-0003-3621-8450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAutism Spectrum Condition (ASC) is characterised by difficulties in social communication and interaction, which may pose significant challenges to daily functioning throughout life. While current diagnostic methods for ASC often rely on measures based on subjective reports, there is a growing need for objective, quantifiable measures to support current clinical assessment of ASC. Eye-tracking technology records eye and gaze movements in real time and provides a direct and objective method for assessing social attention. Integrating eye-tracking within virtual reality (VR) environments presents a novel approach for capturing gaze behaviour in dynamic, ecologically valid social scenarios. This study aims to investigate whether VR-based eye information can reveal group differences in gaze behaviour between autistic adults and neurotypical controls in simulated social interactions.

methodsThis case-control study will include 140 adults diagnosed with ASC and 50 neurotypical controls, matched by age and gender. Participants will engage in six VR-based social scenarios, which vary in social complexity and the presence of non-social distractors. Eye information will be measured using eye-tracking technology integrated into a head-mounted display. Gaze behaviour will be analysed through fixation-based metrics on parameters including number of fixations, mean fixation time, and dwell time, on predetermined Areas of Interest. ANALYSIS: Statistical analyses will assess between-group differences in gaze behaviour as well as correlations between gaze metrics and clinical measures of social functioning, social cognition and symptom severity. DISCUSSION: This study utilises VR-based eye-tracking to investigate novel paradigms for assessing gaze behaviour in ASC in immersive, interactive environments and aims to advance the current understanding of visual social attention in ASC. Positive outcomes from this study may support further research into VR-based eye-tracking to supplement existing clinical assessment methods.

Indexed as

Autism Spectrum DisorderAutistic DisorderEye MovementsFixation, OcularVirtual RealityAdolescentAdultAttentionCase-Control StudiesEye-Tracking TechnologyFemaleHumansMaleMiddle AgedSocial InteractionYoung Adult

Identifiers

PMID40202982
PMCPMC11981225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.