Evidence map›Paper›PMID 40202911›Full record

ArticleChemistry & biodiversity2025

Chemical Composition, Antioxidant, Antimicrobial, Antidiabetic, and Butyrylcholinesterase Inhibitory Activities in Vitro of the Essential Oil and Crude Extracts of the Aerial Parts of Thymus ciliatus.

Nadia Djermane, Mostapha Brahmi, Djallal Eddine Adli, Micaela Gliozzi, Vincenzo Musolino, Rebbas Khellaf, Ramazan Erenler, Rabah Arhab, Stefania Garzoli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Molecules (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nadia DjermaneDepartment of Natural and Life Sciences, Faculty of Exact Sciences and Natural and Life Sciences, Laboratory of Bioactive Molecules and Applications, Larbi Tebessi University, Tebessa, Algeria.
Mostapha BrahmiDepartment of Biology, Faculty of Sciences and Technology, University of Relizane, Relizane, Algeria.
Djallal Eddine AdliDepartment of Biology, Faculty of Sciences, Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of Plants (LBPVBP), University of Dr Moulay Tahar, Saida, Algeria.
Micaela GliozziDepartment of Health Sciences, Laboratory of Pharmaceutical Biology, IRC-FSH Center, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
Vincenzo MusolinoDepartment of Health Sciences, Laboratory of Pharmaceutical Biology, IRC-FSH Center, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
Rebbas KhellafLaboratory of Agro-Biotechnology and Nutrition in Arid and Semi-Arid Areas, Ibn Khaldoun University, Tiaret, Algeria.
Ramazan ErenlerDepartment of Chemistry, Faculty Of Art and Science, Plant Research Laboratory, Tokat Gaziosmanpasa University, Tokat, Turkey.
Rabah ArhabDepartment of Natural and Life Sciences, Faculty of Natural and Life Sciences, Larbi Tebessi University, Tebessa, Algeria.
Stefania GarzoliDepartment of Chemistry and Technologies of Drug, Sapienza University, Rome, Italy.ORCID https://orcid.org/0000-0001-8535-0533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the potential of Thymus ciliatus as a natural source of bioactive compounds by investigating its chemical composition and in vitro biological activities, including antioxidant, antimicrobial, antidiabetic, and anti-Alzheimer properties. The analysis of the essential oil was performed using gas chromatography-mass spectrometry revealing α-terpinenyl acetate (18.74%) and camphor (10.62%) as the major components. Antioxidant activity was evaluated using six methods. Antimicrobial activity was assessed using disc diffusion and well diffusion techniques. Antidiabetic activity was measured through a colorimetric assay, while anti-Alzheimer activity was evaluated against butyrylcholinesterase. The results demonstrated that extracts from polar and medium-polar solvents exhibited the highest antioxidant activity, followed by low-polar solvent extracts. The essential oil of T. ciliatus displayed significant antimicrobial activity, particularly against Staphylococcus aureus, Bacillus cereus, and Candida albicans. Crude extracts also showed antimicrobial activity across all tested strains. The aqueous extract exhibited the strongest antidiabetic activity against α-glucosidase (half-maximal inhibitory concentration [IC

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsHypoglycemic AgentsOils, VolatilePlant ExtractsThymus Plantalpha-GlucosidasesBacillus cereusCandida albicansDose-Response Relationship, DrugMicrobial Sensitivity TestsPlant Components, AerialStaphylococcus aureusalpha-GlucosidasesAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsHypoglycemic AgentsOils, VolatilePlant Extractsantimicrobial activityantioxidant activitybutyrylcholinesterase activityGC‐MSα‐glucosidase

Identifiers

PMID40202911
PMCPMC12351423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.