Evidence map›Paper›PMID 40202900›Full record

ReviewGenetics2025

Chromatin and epigenetics in aging biology.

Eric Lieberman Greer, Siu Sylvia Lee, Veena Prahlad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Reversing aging-like 3D genome disorganization in abioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eric Lieberman GreerDepartment of Pediatrics, Washington University School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-7501-7371
Siu Sylvia LeeDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-5225-4203
Veena PrahladDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.ORCID 0000-0002-0413-6074

Funding

Systematic Analysis of C elegans Longevity DeterminantsR01AG024425 · NIA · CORNELL UNIVERSITY ITHACA · PI Siu Sylvia Lee · 2004 to 2026
$8.5M
Ribosomal RNA Methylation Regulation of Longevity and Stress ResistanceR01AG084739 · NIA · WASHINGTON UNIVERSITY · PI Eric Lieberman Greer · 2023 to 2026
$2.2M
Investigating how stress induced changes in maternal serotonin affect offspring development and stress resilienceR01MH126282 · NIMH · UNIVERSITY OF IOWA · PI Veena Prahlad · 2022 to 2026
$2.1M
NIA NIH HHS R01 AG024425NIA NIH HHS R01AG024425NIA NIH HHS R01 AG084739NIMH NIH HHS R01 MH126282NIMH NIH HHS R01MH126282space
6 · The paper itself

Abstract

This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are deciphered by the cell to impact aging. In this chapter, we will review how chromatin modifications change with age, examine how chromatin-modifying enzymes have been shown to regulate aging and healthspan, discuss how some of these epigenetic changes are triggered and how they can regulate the lifespan of the individual and its naïve descendants, and speculate on future directions for the field.

Indexed as

AgingChromatinEpigenesis, GeneticAnimalsHistonesHumansChromatinHistonesagingchromatinepigeneticshistone modificationsWormBook

Identifiers

PMID40202900
PMCPMC13031114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.