Evidence map›Paper›PMID 40202895›Full record

ReviewThe Journal of general virology2025

Recent advances in the prevention and treatment of respiratory syncytial virus disease.

Alexandra Sanchez-Martinez, Tom Moore, Telma Sancheira Freitas, Tami R Benzaken, Shaun O'Hagan, Emma Millar, Helen E Groves, Simon B Drysdale, Lindsay Broadbent

Abstract readReview
In one paragraph

Review in The Journal of general virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Immune persistence and safety of the AS01Human vaccines & immunotherapeutics · 2025
    Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandra Sanchez-MartinezSchool of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Tom MooreSchool of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Telma Sancheira FreitasSchool of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Tami R BenzakenImmunisations and Vaccine Preventable Disease Division, United Kingdom Health Security Agency, London, UK.
Shaun O'HaganDepartment of Paediatric Infectious Diseases, Royal Belfast Hospital for Sick Children, 274 Grosvenor Rd, Belfast, BT12 6BA, UK.
Emma MillarAcute Paediatric Medical Services, Antrim Area Hospital, Bush Road, Antrim, BT41 2RL, UK.
Helen E GrovesDepartment of Paediatric Infectious Diseases, Royal Belfast Hospital for Sick Children, 274 Grosvenor Rd, Belfast, BT12 6BA, UK.
Simon B DrysdaleOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Lindsay BroadbentSchool of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is associated with considerable healthcare burden; as such, prevention and treatment of RSV have long been considered a priority. Historic failures in RSV vaccine development had slowed the research field. However, the discovery of the conformational change in the RSV fusion protein (F) has led to considerable advancements in the field. The RSV pharmaceutical landscape has drastically changed in recent years with successful trials of both vaccines and second-generation mAbs leading to licensing and roll-out of these agents in several countries. RSV preventative and therapeutic measures will likely have a significant impact on RSV-related morbidity and mortality. However, there are still gaps in the protection that these immunizations offer that should be addressed. Many unanswered questions about RSV infection dynamics and subsequent disease should be a focus of ongoing research. This review discusses the currently licensed RSV pharmaceuticals and others that have recently progressed to clinical trials.

Indexed as

Antiviral AgentsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesAnimalsAntibodies, MonoclonalClinical Trials as TopicHumansViral Fusion ProteinsAntibodies, MonoclonalAntiviral AgentsRespiratory Syncytial Virus VaccinesViral Fusion ProteinsantiviralsmAbsrespiratory syncytial virusvaccines

Identifiers

PMID40202895
PMCPMC12282282

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.