Evidence map›Paper›PMID 40202848›Full record

ArticleCell reports2025

The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states.

Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sanyal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Aman UpadhyayW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA; Graduate Program in Neuroscience, Rutgers Robert Wood Johnson Medical School, Rutgers University, The State University of New Jersey, Piscataway, NJ, USA.
Mark A GradwellW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Thomas J VajtayW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA.
James ConnerMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Arnab A SanyalW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA.
Chloe AzadeganW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA.
Komal R PatelW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA.
Joshua K ThackrayHuman Genetics Institute of New Jersey, Rutgers University, The State University of New Jersey, Piscataway, NJ, USA.
Manon BohicW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Fumiyasu ImaiBurke Neurological Institute, White Plains, NY, USA; Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Simon O OgundareZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Yutaka YoshidaBurke Neurological Institute, White Plains, NY, USA; Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Ishmail Abdus-SaboorZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; Department of Biological Sciences, Columbia University, New York, NY, USA.
Eiman AzimMolecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Victoria E AbrairaW.M. Keck Center for Collaborative Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, New Brunswick, NJ, USA; Brain Health Institute, Rutgers University, Piscataway, NJ, USA. Electronic address: victoria.abraira@rutgers.edu.

Funding

Neural control of skilled movements: an ethological dissection of genetically tractable mammalian motor circuitsDP2NS105555 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2017 to 2022
$3.7M
Defining the anatomical, molecular and functional logic of internal copy circuits involved in dexterous forelimb behaviorsR01NS111479 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2019 to 2023
$2.9M
Using Mouse Pain Scales to Discover Unusual Pain Sensitivity and New Pain TargetsDP2NS130454 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ABDUS-SABOOR, ISHMAIL JOHN · 2022 to 2023
$2.5M
Touching on locomotion: Olise Oputa Diversity Supplement_Nov 15R01NS119268 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI ABRAIRA, VICTORIA EUGENIA GUADALUPE · 2020 to 2024
$2.5M
Functional dissection of cerebellar output circuits that orchestrate limb motor controlRF1NS128898 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN, CHEN, ALBERT · 2022 to 2022
$2.3M
Refining Oxytocin Therapy for Pain: Context is KeyR01NS124799 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI Victoria Eugenia Guadalupe Abraira · 2023 to 2026
$2.0M
Functional dissection of cerebellar output circuits that orchestrate limb motor controlR01NS128898 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EIMAN AZIM, Albert Chen · 2025 to 2026
$1.3M
A new mechanistic and technological framework for uncovering the spinal cord neural systems important for functional recovery after injuryK01NS116224 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI ABRAIRA, VICTORIA EUGENIA GUADALUPE · 2020 to 2024
$1.2M
The Role of Distinct Dorsal Column Nuclei Outputs in Persistent PainK99NS133476 · NINDS · RUTGERS, THE STATE UNIV OF N.J. · PI GRADWELL, MARK · 2024 to 2025
$261k
NINDS NIH HHS DP2 NS105555NINDS NIH HHS DP2 NS130454NINDS NIH HHS K01 NS116224NINDS NIH HHS K99 NS133476NINDS NIH HHS R01 NS111479NINDS NIH HHS R01 NS119268NINDS NIH HHS R01 NS124799NINDS NIH HHS R01 NS128898NINDS NIH HHS RF1 NS128898
6 · The paper itself

Abstract

During pathological conditions, tactile stimuli can aberrantly engage nociceptive pathways leading to the perception of touch as pain, known as mechanical allodynia. The brain stem dorsal column nuclei integrate tactile inputs, yet their role in mediating tactile sensitivity and allodynia remains understudied. We found that gracile nucleus (Gr) inhibitory interneurons and thalamus-projecting neurons are differentially innervated by primary afferents and spinal inputs. Functional manipulations of these distinct Gr neuronal populations bidirectionally shifted tactile sensitivity but did not affect noxious mechanical or thermal sensitivity. During neuropathic pain, Gr neurons exhibited increased sensory-evoked activity and asynchronous excitatory drive from primary afferents. Silencing Gr projection neurons or activating Gr inhibitory neurons in neuropathic mice reduced tactile hypersensitivity, and enhancing inhibition ameliorated paw-withdrawal signatures of neuropathic pain and induced conditioned place preference. These results suggest that Gr activity contributes to tactile sensitivity and affective, pain-associated phenotypes of mechanical allodynia.

Indexed as

HyperalgesiaNeuralgiaAnimalsInterneuronsMaleMiceMice, Inbred C57BLSpinal Cord Dorsal HornTouchbrain stem circuitsCP: NeuroscienceDCNdorsal column nucleilow-threshold mechanoreceptorsLTMRmechanical allodynianeuropathic painpostsynaptic dorsal column neuronsPSDCtactile perception

Identifiers

PMID40202848
PMCPMC12093272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.