Evidence map›Paper›PMID 40202836›Full record

ArticleMolecular biology of the cell2025

Hsp70 chaperones, Ssa1 and Ssa2, limit poly(A) binding protein aggregation.

Hannah E Buchholz, Sean A Martin, Jane E Dorweiler, Claire M Radtke, Adam S Knier, Natalia B Beans, Anita L Manogaran

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hannah E BuchholzDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881.
Sean A MartinDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881.
Jane E DorweilerDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881.
Claire M RadtkeDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881.
Adam S KnierDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881.
Natalia B BeansDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881.
Anita L ManogaranDepartment of Biological Sciences, Marquette University, Milwaukee, WI 53201-1881.ORCID 0000-0003-0844-1479

Funding

Understanding the role of molecular chaperone systems in protein aggregate disassemblyR15GM155860 · NIGMS · MARQUETTE UNIVERSITY · PI MANOGARAN, ANITA L. · 2024 to 2024
$459k
NIGMS NIH HHS R15 GM155860
6 · The paper itself

Abstract

Molecular chaperones play a central role in maintaining protein homeostasis. The highly conserved Hsp70 family of chaperones have major functions in folding of nascent peptides, protein refolding, and protein aggregate disassembly. In yeast, loss of two Hsp70 proteins, Ssa1 and Ssa2, is associated with decreased cellular growth and shortened lifespan. While heterologous or mutant temperature-sensitive proteins form anomalous large cytoplasmic inclusions in

Indexed as

Adenosine TriphosphatasesHSP70 Heat-Shock ProteinsPoly(A)-Binding ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCytoplasmic GranulesHeat-Shock ProteinsHeat-Shock ResponseHSP40 Heat-Shock ProteinsMolecular ChaperonesProtein AggregatesStress GranulesAdenosine TriphosphatasesHeat-Shock ProteinsHsP104 protein, S cerevisiaeHSP40 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsMolecular Chaperonespab1 protein, S cerevisiaePoly(A)-Binding ProteinsProtein AggregatesSaccharomyces cerevisiae ProteinsSIS1 protein, S cerevisiaeSSA1 protein, S cerevisiaeSSA2 protein, S cerevisiae

Identifiers

PMID40202836
PMCPMC12206498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.