Evidence map›Paper›PMID 40202813›Full record

ArticleBiomacromolecules2025

Antibody-Recruiting Surfaces Using Adaptive Multicomponent Supramolecular Copolymers.

Marle E J Vleugels, Esmee de Korver, Simone I S Hendrikse, Sinan Kardas, Shikha Dhiman, Bas F M de Waal, Sandra M C Schoenmakers, Stefan Wijker, Bruno G De Geest, Mathieu Surin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marle E J VleugelsLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.ORCID 0000-0002-6686-3568
Esmee de KorverLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.ORCID 0009-0001-5916-8938
Simone I S HendrikseLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.ORCID 0000-0002-8902-613X
Sinan KardasLaboratory for Chemistry of Novel Materials, Center of Innovation and Research in Materials and Polymers, University of Mons-UMONS, Mons 7000, Belgium.ORCID 0000-0002-4532-8160
Shikha DhimanLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.ORCID 0000-0001-9180-5071
Bas F M de WaalLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.
Sandra M C SchoenmakersLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.
Stefan WijkerLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.ORCID 0000-0002-5037-2393
Bruno G De GeestDepartment of Pharmaceutics, Ghent University, Ghent 9000, Belgium.ORCID 0000-0001-9826-6170
Mathieu SurinLaboratory for Chemistry of Novel Materials, Center of Innovation and Research in Materials and Polymers, University of Mons-UMONS, Mons 7000, Belgium.ORCID 0000-0001-8950-3437
Anja R A PalmansLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.ORCID 0000-0002-7201-1548
E W MeijerLaboratory of Macromolecular and Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.ORCID 0000-0003-4126-7492

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multicomponent structures that mediate the clustering of antibodies on cancer cell surfaces are an attractive strategy to unleash innate immune killing mechanisms. However, covalent multifunctional scaffolds that combine cell surface anchoring and antibody binding can be challenging to synthesize and lack adaptability. Here, we present a dynamic multicomponent supramolecular system displaying both antibody- and cell surface-binding motifs, without covalent linkage between them. Supramolecular monomers based on benzene-1,3,5-tricarboxamide (

Indexed as

AntibodiesPolymersBenzamidesHumansLipid BilayersSurface PropertiesAntibodiesBenzamidesbenzene-1,3,5-tricarboxamideLipid BilayersPolymers

Identifiers

PMID40202813
PMCPMC12076489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.