ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2025
Short-lived neutralizing activity against SARS-CoV-2 in newborns of immunized mothers.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pregnancy reduces COVID-19 vaccine immunity against novel variants.NPJ vaccines · 2025Article
- Short-lived neutralizing activity against SARS-CoV-2 in newborns of immunized mothers.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundNewborns under 6 months of age are at high risk of hospitalization for acute respiratory failure following SARS-CoV-2 infection. Herein, we analyzed neonatal protection against SARS-CoV-2 passively acquired after mother vaccination and/or infection (hybrid immunity).
methodsWe enrolled seventy-eight newborns of immunized mothers against SARS-CoV-2 before or during pregnancy, through vaccination and/or infection. Infants were stratified based on the anamnestic lack (SARS-CoV-2 Vaccinated - SV)/presence (SARS-CoV-2 Infected and Vaccinated - SIV) of COVID-19 maternal infection. SARS-CoV-2-specific Neutralizing Activity (NA) in plasma was assessed by virus neutralization assay (vNTA) against the SARS-CoV-2 Omicron strain at delivery (T0), 3 and 6 months after birth (T3 and T6). Cytokine and chemokine profiles in newborns were also analyzed.
resultsAt birth, significantly lower NA was observed in infants of SV compared to that of SIV mothers; NA declined equally in both groups 3 months after delivery. The presence of at least 4 immunizing events in the mother significantly enhances the NA against SARS-CoV-2 in newborns, regardless of the type of immunization (vaccination or hybrid immunity) and of the timing of the last maternal immunization. Finally, cytokines and chemokines plasma levels were high at birth in all newborns, followed by a decline over the subsequent month.
conclusionOur findings suggest that, independently of a previous SARS-CoV-2 infection or vaccination, it is reasonable to upgrade the recommendation of a booster dose during pregnancy to a "strongly recommended" status, with a view to conferring protection to newborns in the first months after delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.