Evidence map›Paper›PMID 40202785›Full record

ReviewACS sensors2025

Advances on Electrochemiluminescent Biosensors for TB Biomarkers.

Meleskow Cox, Jaymi January, Kefilwe Vanessa Mokwebo, Sodiq T Yussuf, Nelia Abraham Sanga, Zandile Dennis Leve, Samantha Fiona Douman, Emmanuel Iheanyichukwu Iwuoha

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meleskow CoxSensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.ORCID 0000-0003-3609-1277
Jaymi JanuarySensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.ORCID 0000-0002-2499-9934
Kefilwe Vanessa MokweboSensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.
Sodiq T YussufSensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.
Nelia Abraham SangaSensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.
Zandile Dennis LeveSensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.
Samantha Fiona DoumanSensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.
Emmanuel Iheanyichukwu IwuohaSensorLab (University of the Western Cape Sensor Laboratories), Chemical Building University of the Western Cape, Bellville, 7535, Cape Town, South Africa.ORCID 0000-0001-6102-0433

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is a highly contagious bacterial infection that remains a leading cause of death and persistent threat to global health. The spread of TB is exacerbated by the major limitations of conventional diagnostic approaches, such as complex technicalities, high cost, and low sensitivity. To address these challenges, recent research has focused on using electrochemiluminescence (ECL) as an alternative detection strategy coupled to biosensors. ECL biosensors leverage electrochemically generated chemiluminescence, converting electrical energy to light, as a novel transduction mechanism for TB biosensors. This unique approach offers several advantages, namely, wide linear dynamic ranges, improved device sensitivities, and prompt response times for sensitive early detection. This Review offers a comprehensive overview of advancements in ECL biosensor configurations, including detection and amplification strategies, substrates, and the development of luminophores and coreactants tailored for TB biomarker detection. The focus is on ECL biosensor designs, including biorecognition elements like immunosensors, DNA sensors, and aptasensors, along with various immobilization strategies tailored to target specific TB biomarkers. A comprehensive discussion spans biomarker detection trends over the past decade, clinical relevance, sensitivity thresholds, and detection limits. Furthermore, widely recognized TB biomarkers commonly detected in commercial diagnostic tests are discussed alongside novel markers that, while not exclusive to TB, have demonstrated clinical importance. This Review aims to highlight the potential of ECL-based biosensors as an effective means to advance an early, reliable, and accessible TB detection approach.

Indexed as

Biosensing TechniquesElectrochemical TechniquesLuminescent MeasurementsTuberculosisBiomarkersHumansMycobacterium tuberculosisBiomarkersbiomarkersbiosensorsdiagnosticselectrochemiluminescencelimit of detectionlinear dynamic rangeluminophorestuberculosis

Identifiers

PMID40202785
PMCPMC12038885

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.