ArticleChembiochem : a European journal of chemical biology2025
An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products.
Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
The indole moiety is a privileged fragment that frequently populates existing bioactive compound collections. The development of an indole-dearomatization sequence and its application for library expansion of a collection of indole-containing pseudo-natural products (NPs) are described. The resulting compounds are topologically distinct from the original compound class. Phenotyping by means of the cell painting assay initially indicates that the dearomatized compounds are morphologically different than the original pseudo-NP compound class and guiding NPs. However, analysis by means of a new subprofile analysis of the same cell painting assay data indicates that similar morphologies persist throughout the compound classes. Further biological studies support the findings of the subprofile analysis and highlight its potential to more effectively characterize novel compounds. The biological findings suggest that a plethora of indole-dearomatization reactions can be applied to existing indole-containing compound collections to rapidly access new biologically relevant scaffolds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.