ArticleSpine deformity2025
Exploring the potential relationships between idiopathic scoliosis and various multifactorial diseases: a systematic scoping review.
Article in Spine deformity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association of proprioceptive deficits with curve progression and treatment outcomes in subjects with adolescent idiopathic scoliosis: A prospective cohort study with 1 year of follow-up.North American Spine Society journal · 2026Article
- Emerging pathogenetic mechanisms in adolescent idiopathic scoliosis: the role of inflammation and gut microbiota.Journal of orthopaedic surgery and research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the etiology of adolescent idiopathic scoliosis (AIS) remains largely elusive, it is widely recognized as a multifactorial condition shaped by both genetic predispositions and environmental influences. This review seeks to explore the intricate relationships between idiopathic scoliosis and its associated comorbidities, with the goal of advancing our understanding of this multifaceted disorder.
methodsPrimary studies involving human subjects diagnosed with idiopathic scoliosis and presenting comorbid conditions were included. Six online databases (AMED, CENTRAL, CINAHL, EMBASE, MEDLINE, and WOS) were systematically searched. Two reviewers independently screened citations and extracted data. Studies were categorized based on commonly examined diagnoses, and outcome measures were descriptively reported.
resultsOur search yielded 1185 citations, with 9 studies meeting the eligibility after screening. These studies examined comorbidities involving conditions like malocclusion, central precocious puberty (CPP), gingival diseases, malignant hematopoietic neoplasms (MHN), temporomandibular joint disorders (TMD), and functional gastrointestinal disorders (FGD). Significant associations were found between AIS and these multifactorial disorders, including dental anomalies (i.e., asymmetrical canine, midline deviations, crossbites, overbite, multiple malocclusion, gingivitis, distocclusion, asymmetric molar occlusion, maxillary overjet, crowding, and reverse chewing cycles), digestive issues (i.e., FGD), endocrine disruptions (i.e., CPP), musculoskeletal imbalances (i.e., reduced masseter muscle volume, higher Fonseca Anamnestic Index score, and greater Helkimo Clinical Dysfunction Index score), and oncological conditions (i.e., MHN).
conclusionWe have presented the multifactorial and potential systemic nature of AIS by revealing its associations with comorbid conditions. These relationships may indicate shared genetic, hormonal, neuromuscular, and immunological pathways.
Indexed as
Identifiers
40202707What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.