Evidence map›Paper›PMID 40202702›Full record

Observational studyPediatric surgery international2025

Efficacy of sodium bicarbonate Ringer's solution for perioperative fluid management in infants with biliary atresia: a prospective multicenter study.

Hongyi Zhang, Pei Wang, Ruohui Li, Chonggao Zhou, Kuai Chen, Zhe Wen, Yuanmei Liu, Xiang Liu, Qi Chen, Jinfa Tou and 4 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hongyi Zhang *Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, China.
Pei Wang *Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, China.
Ruohui Li *Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, China.
Chonggao ZhouDepartment of Fetal and Neonatal Surgery, Hunan Children's Hospital, Changsha, Hunan, China.
Kuai ChenDepartment of Neonatal Surgery, The Affiliated Children's Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhe WenProvincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Yuanmei LiuDepartment of Pediatric General Thoracic and Urology Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Xiang LiuDepartment of Pediatric Surgery, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Qi ChenDepartment of Pediatric Surgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Jinfa TouDepartment of Neonatal Surgery, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hongxia RenDepartment of Neonatal Surgery, Children's Hospital of Shanxi, Taiyuan, Shanxi, China.
Mingman ZhangDepartment of Hepatobiliary Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China.
Feng ChenDepartment of Pediatric Surgery, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, Fujian, China. cfeng3000@163.com.
Jiexiong FengDepartment of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, China. 2002tj0515@hust.edu.cn.

Funding

Hubei Provincial Key Research and Development Program 2020BCB008Tongji Hospital Clinical Research Flagship Program 2019YBKY026
6 · The paper itself

Abstract

purposeTo evaluate the efficacy and safety of perioperative sodium bicarbonate Ringer's solution (BRS) in biliary atresia (BA) infants undergoing Kasai portoenterostomy (KPE).

methodsThis study was conducted in 11 pediatric medical centers across China from 2020 to 2022. Infants were randomly assigned to either the BRS group (n = 64) or the control crystalloids group (n = 56) for perioperative fluid management. Anesthesia and fluid management were standardized. Primary outcomes were arterial blood pH, bicarbonate, and base excess; secondary outcomes included changes in other blood parameters and adverse events.

resultsThe baseline characteristics of the two groups were similar. During KPE, BRS more effectively maintained arterial blood pH, bicarbonate, and base excess during KPE with no electrolyte abnormalities. Three days after KPE, the BRS group had lower potassium levels. Drug safety evaluation showed no significant differences, and the incidence of adverse events was comparable.

conclusionBRS effectively maintained the acid-base status of BA infants during KPE. With no significant safety concerns, it is suggested that BRS is a suitable option for perioperative fluid management.

Indexed as

Biliary AtresiaFluid TherapyPerioperative CarePortoenterostomy, HepaticSodium BicarbonateChinaFemaleHumansInfantMaleProspective StudiesRandom AllocationTreatment OutcomeSodium BicarbonateBiliary atresiaInfantsKasai portoenterostomySodium bicarbonate Ringer’s solution

Identifiers

PMID40202702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.