Evidence map›Paper›PMID 40202611›Full record

ArticleJournal of neurology2025

Tenecteplase compared to alteplase before mechanical thrombectomy enhances 1-h recanalization and reduces disability in large-vessel occlusion.

Lu Wang, Jialu Li, Xiao Wu, Lulan Li, Xueqiao Jiao, Fengyuan Che, Hongxing Han, Liyong Zhang, Weidong Liu, Peifu Wang and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lu WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Jialu LiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Xiao WuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Lulan LiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Xueqiao JiaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Fengyuan CheDepartment of Neurology, Linyi People's Hospital, Linyi, China.
Hongxing HanDepartment of Neurology, Linyi People's Hospital, Linyi, China.
Liyong ZhangDepartment of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
Weidong LiuDepartment of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
Peifu WangDepartment of Neurology, Aerospace Center Hospital, Beijing, China.
Fuxia YangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Fangfang ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Xunming JiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China.
Xiuhai GuoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, China. guoxhxuan@126.com.ORCID http://orcid.org/0000-0001-6576-0033

Funding

Capital's Funds for Health Improvement and Research 2024-1-2011National Nature Science Foundation of China 82171302National Science and Technology Major Project 2023ZD0503806
6 · The paper itself

Abstract

backgroundThe comparative efficacy of tenecteplase versus alteplase in achieving early recanalization (ER) before mechanical thrombectomy (MT) for large-vessel occlusion (LVO) remains uncertain.

methodsThis study was a retrospective analysis of prospectively collected data of consecutive patients with LVO underwent intravenous thrombolysis (IVT) and brain angiography between January 2022 and December 2023. ER was defined as ≥ 50% reperfusion or absence of retrievable thrombus on initial angiography.

results146 patients received tenecteplase and 307 received alteplase. Tenecteplase shortened door-to-IVT time (33 vs. 39 min, P < 0.001) and door-to-puncture time (97 vs. 109 min, P = 0.039) compared to alteplase. Overall ER rates did not differ significantly (17.1% vs. 12.1%, P = 0.223). However, a significant interaction was observed between thrombolytic agent and IVT-to-puncture time (P

conclusionsReal-world observations reveal tenecteplase has increased ER rates compared to alteplase within 1 h of IVT and reduced disability in LVO patients. Further randomized trials are warranted to evaluate the effect of tenecteplase rapid bridging mechanical thrombectomy.

Indexed as

Fibrinolytic AgentsIschemic StrokeTenecteplaseThrombectomyTissue Plasminogen ActivatorAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTime-to-TreatmentFibrinolytic AgentsTenecteplaseTissue Plasminogen ActivatorAlteplaseBridging therapyLarge-vessel occlusionStrokeTenecteplase

Identifiers

PMID40202611
PMCPMC11982149

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.