Evidence map›Paper›PMID 40202602›Full record

SynthesisEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Antimicrobial stewardship interventions in hospitalized adults with community-acquired pneumonia: a systematic review and meta-analysis.

Nurgul Ablakimova, Svetlana Rachina, Heshan Radeesha de Silva, Anna Vlasenko, Gaziza Smagulova, Aigul Mussina, Svetlana Sakhanova, Aliya Zhylkybekova, Bibigul Tleumagambetova, Dinara Karimoldayeva and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nurgul AblakimovaDepartment of Pharmacology, Clinical Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan. n.ablakimova@zkmu.kz.
Svetlana RachinaHospital Therapy Department No. 2, I.M.Sechenov First Moscow State Medical University, Moscow, Russia.
Heshan Radeesha de SilvaHospital Therapy Department No. 2, I.M.Sechenov First Moscow State Medical University, Moscow, Russia.
Anna VlasenkoLLC Digital Technologies and Platforms, Moscow, Russia.
Gaziza SmagulovaDepartment of Pharmacology, Clinical Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Aigul MussinaDepartment of Pharmacology, Clinical Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Svetlana SakhanovaScientific and Practical Center, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Aliya ZhylkybekovaDepartment of Pathological Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Bibigul TleumagambetovaDepartment of Internal Diseases No. 1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Dinara KarimoldayevaRespiratory Medicine and Allergology Department, Aktobe Medical Center, Aktobe, Kazakhstan.
Sarkyt KozhantayevaDepartment of Otolaryngology and Ophtalmology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis systematic review and meta-analysis evaluate the effectiveness of ASPs in managing community-acquired pneumonia (CAP), focusing on antibiotic optimization and resistance mitigation.

methodsComprehensive literature searches were conducted in PubMed, Scopus, and Web of Science using PICOS criteria. Studies involving adults with CAP exposed to ASPs were included. Data on clinical, economic, diagnostic, and treatment outcomes were extracted. Random-effects meta-analysis using R software pooled effect sizes. Outcomes reported in at least three studies were analyzed for robustness.

resultsASPs did not significantly impact in-hospital mortality, length of stay, 30-day readmissions, sample collection rates, or intravenous antibiotic duration. However, notable improvements included shorter time to clinical stability and a 31% reduction in 30-day mortality. Legionella urinary antigen testing frequency increased nearly threefold, and the time from admission to antibiotic initiation was reduced. Enhanced adherence to timely antibiotic administration and recommended regimens was observed, though outcome variability persisted.

conclusionASPs significantly improve CAP management by enhancing clinical stability and accelerating antibiotic initiation. Multifaceted strategies, including rapid diagnostics and clinician education, yield clinical benefits. However, outcome variability suggests a need for tailored interventions. Future research should isolate specific ASP components influencing prescriber behavior. Ongoing investment in education, diagnostics, and interdisciplinary collaboration is vital to optimize CAP treatment and combat antibiotic resistance.

Indexed as

Anti-Bacterial AgentsAntimicrobial StewardshipCommunity-Acquired InfectionsPneumoniaAdultCommunity-Acquired PneumoniaHospitalizationHumansTreatment OutcomeAnti-Bacterial AgentsAttitudesCommunity-acquired infectionsDisease managementHealth knowledgePneumoniaPractice

Identifiers

PMID40202602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.