ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Treatment of pre-extensively drug-resistant tuberculosis in a 4-month-old infant using a regimen of bedaquiline, delamanid, and contezolid.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparative analysis of clinical manifestations between congenital and non-congenital tuberculosis in infants.BMC infectious diseases · 2026Article
- Towards precision dosing of contezolid: moderate hepatic impairment increases plasma concentration of contezolid in anti-tuberculosis treatment.BMC infectious diseases · 2026Observational
- The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review.Infectious diseases and therapy · 2026Review
- Prevalence and distribution patterns of drug resistance inMicrobiology spectrum · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-resistant tuberculosis (TB) is a significant global challenge, especially in children, where diagnosis and treatment are difficult. This report describes a 4-month-old male infant with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) successfully treated with bedaquiline, delamanid, and contezolid. The patient, born prematurely, developed severe pulmonary TB after exposure to drug-resistant TB from the mother. After discontinuing the initial regimen due to adverse effects, the adjusted regimen resulted in negative TB culture conversion, significant pulmonary improvement, and no notable adverse effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.