ArticleJournal of neuro-oncology2025
Repeat stereotactic radiosurgery for recurrent brain metastases: a retrospective comparison of local progression and distant brain metastases after prior radiosurgery.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment modalities in recurrent brain metastases: a combined institutional and individual patient data meta-analysis of post-recurrence survival and local progression-free survival.Journal of neuro-oncology · 2025Pooled it
- Outcomes in long-term survivors treated with stereotactic cranial radiotherapy for brain metastases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Precision reirradiation in recurrent CNS tumors integrating biology techniques and multimodal care.Discover oncology · 2026Review
- Fractionated repeat Gamma Knife stereotactic radiosurgery for locally recurrent brain metastases.Journal of radiosurgery and SBRT · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimThis study evaluated the efficacy and safety of repeat stereotactic radiosurgery (SRS) for recurrent brain metastases (BMs), focusing on failure patterns of local progression (LP) and distant brain metastases (DBM).
methodsPatients who underwent first-time SRS for newly diagnosed BMs (2011-2022) and repeat SRS (until June 2024) were included. Treatment courses were first-time or repeat SRS, with repeat SRS classified as LP and DBM. The primary endpoint was the 1-year local control rate (LCR). Secondary endpoints included survival and radiation necrosis (RN) incidence.
resultsAmong 723 courses (427 patients, 4,524 BMs), 404 (141 patients, 2,924 BMs) met criteria. First-time SRS was performed in 141 courses (775 BMs), and repeat SRS in 263 (2,149 BMs), including 45 LP (38 patients, 224 BMs) and 218 DBM (126 patients, 1,925 BMs). The median age was 65 years, and 75.9% had lung cancer. LP had a longer interval from prior SRS (12.6 vs. 6.3 months, P < 0.001) but similar follow-up (12.4 vs. 13.7 months). The 1-year LCR was lower in LP (72.4% vs. 88.3%, P = 0.0022), though survival was similar (17.9 vs. 16.3 months). LP had higher RN incidence (20.6% vs. 5.7%, P < 0.001) and symptomatic RN (13.3% vs. 2.8%, P < 0.001). Multivariate analysis identified LP failure as a significant factor for increased local failure (subdistribution hazard ratio [SHR] 2.35, P = 0.039) and RN (SHR 3.41, P < 0.001).
conclusionsDespite similar survival, LP failure was associated with lower LCR and higher RN incidence, highlighting the need for optimized repeat SRS strategies.
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Identifiers
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Registered trials
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