ArticleRice (New York, N.Y.)2025
Microrchidia OsMORC6 Positively Regulates Cadmium Tolerance and Uptake by Mediating DNA Methylation in Rice.
Article in Rice (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- miR408-5p and miR408-3p cooperatively reduce cadmium uptake and accumulation in rice.PLoS biology · 2026Article
- Overexpression of the glutathione synthase gene PsGSH2 enhances cadmium stress tolerance in transgenic Arabidopsis thaliana.Plant cell reports · 2025Article
- DNA Methylation in Rice: Mechanisms, Regulatory Roles, and Beyond.International journal of molecular sciences · 2025Review
- Epigenetics in Plant Response to Climate Change.Biology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Rice (Oryza sativa) is an extremely important global food crop. However, cadmium (Cd) contamination in paddy fields poses a serious threat to human health worldwide. To generate low-Cd or Cd-free rice germplasms, it is essential to understand the molecular mechanisms involved in Cd tolerance, uptake, and translocation from soil to plant. In this study, we identify three Microrchidia proteins, OsMORC6a, OsMORC6b, and OsMORC6c, that regulate Cd tolerance and accumulation, although they do not alter the translocation of Cd from roots to shoots. Knockout of all three genes results in reducing Cd accumulation and increasing sensitivity to Cd stress. Furthermore, transcriptome analysis reveals 1,127 differentially expressed genes (DEGs) in the morc6abc mutants, which are significantly enriched in 'plant-type cell wall' and 'oxidoreductase activity' pathways. Through an integrating DNA methylome and transcriptome data, we identify 247 hyper-DMR-associated DEGs and 325 hypo-DMR-associated DEGs in morc6abc mutants. Gene Ontology (Go) enrichment analysis reveals that OsMORC6 proteins positively regulate Cd tolerance and uptake by mediating DNA methylation, which regulates the proper expression of genes related to plant cell wall and oxidative stress under Cd stress. Taken together, our findings reveal novel genes that mediate Cd tolerance and accumulation by affecting DNA methylation, offering valuable resource for breeding low-Cd or Cd-free rice germplasms.
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Registered trials
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