ArticleAlimentary pharmacology & therapeutics2025
Three-Dimensional Transjugular Intrahepatic Portosystemic Shunt Geometry Predicts Shunt Dysfunction.
Article in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03628807 (Non-invasive Evaluation of Prognostic Parameters for Patients With Transjugular Intrahepatic Portosystemic Shunt), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive Evaluation of Prognostic Parameters for Patients With Transjugular Intrahepatic Portosystemic Shunt (TIPS) Using a Structured Follow up Protocol
Who cites it
2 citing papers in PubMed.
- Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt Using Dedicated versus Generic Stent-Grafts in Cirrhotic Patients.Cardiovascular and interventional radiology · 2026Article
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Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundPatients with decompensated cirrhosis are at risk of portal hypertension-related complications, such as refractory ascites or variceal bleeding. Transjugular intrahepatic portosystemic shunt (TIPS) insertion is the most effective treatment to reduce portal hypertension. However, patients are at risk for TIPS dysfunction.
aimsWe aimed to investigate the prognostic value of three-dimensional (3D) TIPS geometry in predicting TIPS dysfunction.
methodsA total of 107 patients who underwent TIPS insertion between 2014 and 2019 and received a computed tomography (CT) scan after TIPS insertion during routine clinical practice were included. We used a semiautomated algorithm and multiplanar reconstructions of these CT scans to calculate parameters of 3D TIPS geometry. The primary outcome of this study was the development of TIPS dysfunction (defined as need for invasive TIPS revision). To identify predictors for the development of TIPS dysfunction, Cox regression analyses were performed with TIPS dysfunction as the endpoint.
resultsThirty-two patients developed TIPS dysfunction and were compared to the dysfunction-free 75 patients. A larger distance from the cranial TIPS stent end to the vena cava inferior (p < 0.001, HR 1.061, 95% CI 1.030-1.093) and the maximum stent curvature (p = 0.003, HR 1.020, 95% CI 1.007-1.034) were significantly associated with TIPS dysfunction in a multivariate Cox regression analysis.
conclusionA more pronounced stent curvature and a longer cranial stent distance from the inferior vena cava were identified as independent predictors of TIPS dysfunction. Interventionalists should choose a more central and less curved TIPS tract during the TIPS procedure to reduce the risk of development of TIPS dysfunction.
trial registrationThis retrospective monocentric study includes patients from the NEPTUN cohort (registered at ClinicalTrials.gov; Identifier: NCT03628807).
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