Evidence map›Paper›PMID 40202335›Full record

ArticleAntimicrobial agents and chemotherapy2025

Phenotypic and genotypic resistance to bedaquiline in patients with multi-drug-resistant tuberculosis-experiences from Armenia.

E Ardizzoni, W Mulders, M De Diego Fuertes, A Hayrapetyan, A Mirzoyan, J Faqirzai, N Khachatryan, I Oganezova, F Varaine, M Bastard and 7 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Transmission of bedaquiline-resistant Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.American journal of respiratory and critical care medicine · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

E ArdizzoniInstitute of Tropical Medicine, Antwerp, Belgium.ORCID 0000-0003-3562-9194
W MuldersInstitute of Tropical Medicine, Antwerp, Belgium.
M De Diego FuertesUniversity of Antwerp Faculty of Medicine and Health Sciences, Wilrijk, Flanders, Belgium.
A HayrapetyanNational Tuberculosis Control Centre of Armenia, Yerevan, Armenia.
A MirzoyanNational Reference Laboratory of Armenia, Yerevan, Armenia.
J FaqirzaiMédecins Sans Frontières, Paris, France.
N KhachatryanMédecins Sans Frontières, Yerevan, Armenia.
I OganezovaMédecins Sans Frontières, Yerevan, Armenia.
F VaraineMédecins Sans Frontières, Paris, France.
M BastardEpicentre, Paris, Île-de-France, France.
P GraulusInstitute of Tropical Medicine, Antwerp, Belgium.
C J MeehanInstitute of Tropical Medicine, Antwerp, Belgium.
L RigoutsInstitute of Tropical Medicine, Antwerp, Belgium.ORCID 0000-0003-3301-9480
B C de JongInstitute of Tropical Medicine, Antwerp, Belgium.
T DecrooInstitute of Tropical Medicine, Antwerp, Belgium.
C Hewison *Médecins Sans Frontières, Paris, France.
A Van Rie *University of Antwerp Faculty of Medicine and Health Sciences, Wilrijk, Flanders, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Risk factors for baseline bedaquiline (BDQ) resistance, amplification during treatment, and correlations with treatment outcomes are not fully understood. This cohort included Armenian patients with multidrug-resistant TB predominantly fluoroquinolone-resistant enrolled between 2013 and 2015 in a BDQ compassionate use program. BDQ resistance at baseline and during treatment was assessed using MGIT (pDST

Indexed as

Antitubercular AgentsDiarylquinolinesMycobacterium tuberculosisTuberculosis, Multidrug-ResistantAdultAgedArmeniaDrug Resistance, Multiple, BacterialFemaleGenotypeHumansMaleMicrobial Sensitivity TestsMiddle AgedMutationPhenotypeAntitubercular AgentsbedaquilineDiarylquinolinesArmeniabedaquilineMDR-TBmutationsWGS

Identifiers

PMID40202335
PMCPMC12057352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.