ArticleJournal of the American Chemical Society2025
Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ-Cyclodextrin.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates.Nature communications · 2026Article
- Sweet molecular containers.Nature chemistry · 2026Article
- Cyclodextrins, Surfactants and Their Inclusion Complexes.Molecules (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
α-, β-, and γ-cyclodextrins (CDs) are macrocycles formed from six, seven, and eight α-1,4-linked d-glucopyranose units and are industrially produced on ton scales for use as hosts for bioactive guests in foods, cosmetics, and pharmaceuticals. Large-ring cyclodextrins, with more than eight glucose units, have been known for decades but never isolated in more than milligram quantities. We report a scalable method to synthesize δ-CD, formed from nine glucose units, in high yield (>40%), high purity (>95% purity without chromatography), and unprecedented quantities (multigram scale). We exploit a superchaotropic dodecaborate template, B
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Registered trials
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