Evidence map›Paper›PMID 40202173›Full record

ArticleAutophagy2025

Overlapping functions between

Marina Sampaio Cruz, Ana Maria Manso, Angel Soto-Hermida, Paul Bushway, Elizabeth Silver, Betul Beyza Gunes, Zhiyuan Tang, Giovanni Gonzalez, Sharon Lau, Jordan Arbayo and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marina Sampaio CruzDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Ana Maria MansoDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Angel Soto-HermidaDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Paul BushwayDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Elizabeth SilverDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Betul Beyza GunesDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Zhiyuan TangDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Giovanni GonzalezDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Sharon LauDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Jordan ArbayoDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Rita H NajorSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Liguo ChiSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Yusu GuDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Wei FengDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Randy T CowlingDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Asa B GustafssonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Ju ChenDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Eric D AdlerDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Secretion of mitochondria as a cellular quality control mechanismR01HL155281 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUSTAFSSON, ASA B. · 2021 to 2024
$2.3M
Novel function of a mitochondria phosphatase in cardiac developmentR01HL157119 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2021 to 2024
$2.2M
Nuclear envelope protein LEMD2 in heartR01HL158981 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2021 to 2024
$2.2M
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
NHLBI NIH HHS R01 HL155281NHLBI NIH HHS R01 HL157119NHLBI NIH HHS R01 HL158981NIH HHS S10 OD023527NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

LAMP2 is a ubiquitously expressed protein critical for autophagy. Alternative splicing gives rise to three isoforms. However, the roles of major LAMP2 isoforms in the heart are not known. To address this knowledge gap, we generated

Indexed as

AutophagyLysosomal-Associated Membrane Protein 2MyocardiumAnimalsAutophagosomesFibrosisMiceMice, KnockoutProtein IsoformsLysosomal-Associated Membrane Protein 2Protein IsoformsAutophagycompensatory mechanismheart functionLAMP2ALAMP2Bmouse model

Identifiers

PMID40202173
PMCPMC12366817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.