Trial reportJournal of cosmetic dermatology2025
Efficacy and Skin Acceptability of a Cosmetic Cream for Nasolabial Dryness and Irritation.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
Abstract
introductionRhinorrhea is a widespread condition related to common upper respiratory insults such as influenza and rhinitis, often accompanied by frequent nose cleansing resulting in skin irritation. This study evaluated the cutaneous acceptability and nourishing, soothing, protecting, and moisturizing effects of Sterimar Soothing Nose Cream on the skin around the nose in healthy adults.
methodsWe conducted an exploratory single-arm clinical trial in 33 adults (mean age 46 years) who blow their nose often (> 5 times/day) due to a cold or allergies and have sensitive, irritated/dry nose. Participants applied the cream topically on their noses twice daily for 14 days. Cutaneous acceptability and efficacy measures were assessed by participants and by the study dermatologist before, during, and after 14 days. Skin imaging analysis via the Visia camera system and skin hydration via Corneometer were also assessed. Participants also completed a questionnaire about overall product performance.
resultsThe dermatologist noted reduced (p < 0.001) redness, swelling, dryness, roughness, and itchiness, with improved (p < 0.001) hydration, softness, and flexibility after 7 and 14 days. Participants reported less (p < 0.05) dryness, redness, and discomfort, with 97% rating the cream's soothing effect as moderate to strong. The cream also increased (p < 0.0001) skin hydration by 14%, measured by Corneometer 30 min postapplication. No worsening of symptoms or adverse effects was reported. All participants found the cream pleasant, with most intending to purchase and continue use.
conclusionsThe results indicate that Sterimar soothing nose cream is effective in nourishing, soothing, protecting, and moisturizing the nasolabial zone, and is well tolerated.
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