ArticleMovement disorders : official journal of the Movement Disorder Society2025
Noninvasive Temporal Interference Stimulation of the Subthalamic Nucleus in Parkinson's Disease Reduces Beta Activity.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non-Invasive Brain Stimulation for Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Hotspots and trends in acupuncture combined with non-invasive neuromodulation technology in the past 20 years: a bibliometric analysis.Frontiers in neurology · 2025Pooled it
- Temporal Interference Stimulation Modulates Resting State Functional Connectivity of Motor Circuit in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Trial
- Multifocal Noninvasive Deep Brain Stimulation to Enhance Cognition in Mild Cognitive Impairment: A Crossover Trial.JAMA network open · 2026Trial
- Trial
- Personalized high-intensity temporal interference stimulation decouples cerebellar networks to enhance implicit learning.Journal of neuroengineering and rehabilitation · 2026Trial
- Optimizing tACS for working memory: differential outcomes in healthy aging and non-amnestic mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- A patient-specific, 3D printed neurostimulator enabling focal transcranial electrical stimulation and EEG at home.Journal of neuroengineering and rehabilitation · 2025Trial
- Duration-dependent attenuation of nucleus accumbens synchronisation via noninvasive temporal interference.General psychiatry · 2026Article
- Temporal Interference Stimulation of Centromedian-Parafascicular Complex in Disorders of Consciousness: A Pilot Study.Annals of clinical and translational neurology · 2026Article
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Mapping the Global Trajectory and Key Trends of Temporal Interference Stimulation.Bioengineering (Basel, Switzerland) · 2026Article
- Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS.NeuroImage · 2026Article
- Temporal Interference Electrical Stimulation for Neuropsychiatric Disorders: Mechanisms, Applications, and Translational Perspectives.International journal of molecular sciences · 2026Review
- [Electric-field modeling, simulation, and experimental analysis of multi-target temporal interference transcranial alternating current stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Neuromodulation-induced normalization of cortical metastable dynamics signatures in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Review
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Ventral striatum temporal interference brain stimulation enhances the reward positivity event-related potential and reduces anxiety.Research square · 2026Article
- Transcranial Temporal Interference Stimulation: A Brief Review of Architectures, Circuits, and Application Challenges.IEEE open journal of engineering in medicine and biology · 2026Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundTemporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high-frequency signals (f
objectiveThe goals of this study were to verify the capability of TIS to modulate the subthalamic nucleus (STN) with Δf and to compare the effect of TIS and conventional deep brain stimulation (DBS) on the STN beta oscillations in patients with Parkinson's disease (PD).
methodsDBS leads remained externalized after implantation, allowing local field potentials (LFPs) recordings in eight patients with PD. TIS was performed initially by two pairs (f
resultsThe comparison between the baseline LFPs and recordings after TIS and conventional DBS sessions showed substantial suppression of high beta power peak after both types of stimulation in all patients.
conclusionsTIS has the potential to effectively modulate the STN and reduce the beta oscillatory activity in a completely noninvasive manner, as is traditionally possible only with intracranial DBS. Future studies should confirm the clinical effectiveness of TIS and determine whether TIS could be used to identify optimal DBS candidates and individualize DBS targets. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.