Evidence map›Paper›PMID 40201884›Full record

ArticleCureus2025

Successful Treatment of TAFRO (Thrombocytopenia, Anasarca, Fever, Renal Insufficiency, and Organomegaly) Syndrome With Triple Combination Therapy of Corticosteroid, Tocilizumab, and Cyclosporine: A Case Report.

Junki Morino, Keiji Hirai, Katsuyuki Yoshida, Shinichi Kako, Susumu Ookawara, Hisashi Oshiro, Hitoshi Sugawara, Yoshiyuki Morishita

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junki MorinoDivision of Nephrology, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Keiji HiraiDivision of Nephrology, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Katsuyuki YoshidaDivision of General Medicine, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Shinichi KakoDivision of Hematology, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Susumu OokawaraDivision of Nephrology, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Hisashi OshiroDepartment of Diagnostic Pathology, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Hitoshi SugawaraDivision of General Medicine, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Yoshiyuki MorishitaDivision of Nephrology, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of the most severe grade TAFRO (thrombocytopenia, anasarca, fever, renal insufficiency, and organomegaly) syndrome that was successfully treated with triple combination therapy of corticosteroid, tocilizumab and cyclosporine. A 48-year-old man with a history of thrombotic thrombocytopenic purpura was referred to our department for dyspnea, pleural effusion, and ascites. Further examination revealed thrombocytopenia (platelet count 4.7×10

Indexed as

acute renal failurecorticosteroidcyclosporinetafro syndrometocilizumab

Identifiers

PMID40201884
PMCPMC11976031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.