ArticleEClinicalMedicine2025
Prognostic value of baseline EORTC QLQ-C30 scores for overall survival across 46 clinical trials covering 17 cancer types: a validation study.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Appetite loss during chemotherapy is associated with reduced dietary intake and quality of life in patients with gynecologic cancer: a prospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Feasibility of an exercise intervention for chemotherapy-related fatigue in patients with gynecologic cancer: a randomized controlled trial with multidimensional assessment.BMC sports science, medicine & rehabilitation · 2026Article
- Dietary Habits, Nutritional Knowledge, and Quality of Life Among Patients with Gastrointestinal Cancers: An Exploratory Cross-Sectional Survey.Journal of clinical medicine · 2026Article
- Optimal mind-body exercise for quality of life, anxiety, and depression in cancer patients and survivors: A pairwise, network, and dose-response meta-analysis of randomized controlled trials.Applied psychology. Health and well-being · 2026Article
- Quality of life and care experiences in a US multi-institutional neuroendocrine tumor cohort.Journal of the National Cancer Institute · 2026Article
- Trajectories of patient-reported outcomes among diverse cancer patients in ambulatory oncology clinics.Journal of cancer survivorship : research and practice · 2026Article
- Patient-Reported Quality of Life Predicts First-Cycle Pharmacotherapy Survival in Breast Cancer: A Prospective Cohort Study.Medical sciences (Basel, Switzerland) · 2026Article
- Health-Related Quality of Life Changes in Patients with Digestive Cancers and Chronic Digestive Diseases: A Prospective, Multicenter Study.Journal of clinical medicine · 2026Article
- Clinical and socioeconomic determinants of health-related quality of life among cancer patients in Southwestern Iran: a cross-sectional study.Scientific reports · 2026Article
- Models, outcomes, barriers, and facilitators of supportive care in cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities.Molecular oncology · 2026Article
- Preferences and reasons for clothing colors in women patients and survivors of breast cancer in Korea.PloS one · 2026Article
- Health-Related Quality of Life and Symptom Burden in Patients with Diffuse Large B-Cell Lymphoma Before Treatment with Tafasitamab and Lenalidomide: An Ad Hoc Analysis of Italian Real-World Data from the PRO-MIND Study.Diseases (Basel, Switzerland) · 2025Article
- Trajectories of Patient-Reported Outcomes among Diverse Cancer Patients in Ambulatory Oncology Clinics.Research square · 2025Article
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Authors and funding
38 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: A pooled data analysis by Quinten et al. (2009) found three European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) health-related quality of life (HRQoL) scales to be prognostic for survival: physical functioning, pain and appetite loss. This study aims to replicate these findings in an independent data set comprising a broader cancer population. Methods: Data were obtained from 46 clinical trials across three cancer research networks conducted between 1996 and 2013 that assessed HRQoL using the EORTC QLQ-C30. A stratified Cox proportional hazards model was employed to assess the prognostic significance of baseline QLQ-C30 scale scores on overall survival, adjusting for socio-demographic and clinical variables. Stepwise model selection was done at 5% significance level. Model stability and prognostic accuracy were evaluated via bootstrapping and the Findings: Data from 16,210 patients reporting HRQoL at baseline, spanning 17 cancer types, was used. The stratified multivariable model confirmed that better physical functioning (hazard ratio [HR], 0.94; 95% confidence interval [CI], 0.93-0.96), lower pain (HR, 1.02; 95% CI, 1.01-1.03), and appetite loss (HR, 1.04; 95% CI, 1.03-1.05) were significantly associated with survival. Additionally, global health status/QoL, dyspnoea, emotional and cognitive functioning were found to be prognostic for survival. This final model, encompassing sociodemographic, clinical, and HRQoL variables, achieved a corrected Interpretation: These results support previous findings that baseline physical functioning, pain, and appetite loss scores, along with four other scales from the EORTC QLQ-C30, predict survival in cancer patients. Funding: EORTC Quality of Life Group.
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