Evidence map›Paper›PMID 40201686›Full record

ArticleFrontiers in pharmacology2025

Potential effects of lipid lowering and antioxidant activity of exosomes from Phascolosoma esculenta:

Lin Yang, Xue Yi, Meitao Duan, Ahmed Mahal, Binbin Chen, Zhiqiang Zhang, Jungang Ren, Ming Chen, Chen Meng, Moxun Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lin Yang *College of Pharmacy, Jiamusi University, Jiamusi, China.
Xue Yi *Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, China.
Meitao Duan *Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, China.
Ahmed MahalDepartment of Medical Biochemical Analysis, College of Health Technology, Cihan University-Erbil, Erbil, Iraq.
Binbin ChenDepartment of Pharmacy, Xiamen Xianyue Hospital, Xiamen, Fujian, China.
Zhiqiang ZhangKey Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, China.
Jungang RenKey Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, China.
Ming ChenKey Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, China.
Chen MengCollege of Pharmacy, Jiamusi University, Jiamusi, China.
Moxun XuCollege of Pharmacy, Jiamusi University, Jiamusi, China.
Ahmad J ObaidullahDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Chen WangKey Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, China.
Mingyuan LiuCollege of Pharmacy, Jiamusi University, Jiamusi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes released from cells have been shown to play an important role in health and disease due to their potential application in therapy and diagnosis. First of all, we extracted the exosome from Phascolosoma esculenta, and studied the lipid lowering and antioxidant activity of Phascolosoma esculenta exosome. It was found that Phascolosoma esculenta exosomes could significantly decrease the lipid accumulation caused by oleic acid, and improve triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL-C). The exosomes of Phascolosoma esculenta also exhibit antioxidant activity, which can decrease the amount of reactive oxygen species (ROS) and malondialdehyde (MDA), and raise the level of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC). The exosomes of Phascolosoma esculenta have the function of reducing lipid and antioxidation.

Indexed as

antioxidantexosomeshypolipidemiclipid loweringphascolosoma esculenta

Identifiers

PMID40201686
PMCPMC11976164

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.