ArticleHeart rhythm O22025
Adjunctive posterior wall isolation for patients with persistent atrial fibrillation: A systematic review and meta-analysis.
Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Pulsed-field vs radiofrequency ablation for posterior wall isolation in persistent atrial fibrillation: A propensity-matched outcome analysis.Heart rhythm O2 · 2026Article
- A randomized controlled trial of pulsed field ablation vs antiarrhythmic therapy as a first-line treatment for persistent atrial fibrillation: The AVANT GUARD trial rationale and design.Heart rhythm O2 · 2026Article
- Biomarker response to balloon-in-basket pulsed field ablation: does posterior wall isolation matter?Frontiers in cardiovascular medicine · 2026Article
- Feasibility, Acute Efficacy and Safety of Empirical Superior Vena Cava Isolation in Addition to Pulmonary Vein Isolation Using the Fourth-Generation Cryoballoon: Insights from a Randomized Trial.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. Its effectiveness for persistent atrial fibrillation (PeAF) is limited, and the benefits of adjunctive posterior wall ablation are uncertain. Objective: The purpose of this study was to perform a systematic review and meta-analysis of PVI with/without adjunctive PWI in patients with PeAF. Methods: We systematically searched PubMed, Embase, Cochrane, and ClinicalTrials.gov databases for randomized controlled trials (RCTs) comparing PVI with/without PWI in patients with PeAF. Random-effects model was used for the meta-analysis. Atrial tachyarrhythmia (ATA) was a composite of AF, atrial flutter, or atrial tachycardia. Results: Our meta-analysis included eight RCTs with 1104 patients (546 PVI, 558 PVI plus PWI). Compared with PVI alone, adjunctive PWI significantly increased freedom from ATA recurrence (relative risk [RR] 1.13, 95% confidence interval [CI] 1.01-1.27, Conclusion: Our findings support that adjunctive PWI to PVI is an effective strategy compared with PVI alone for reducing ATA recurrence in patients with PeAF without compromising safety. Notably, patients with long-standing PeAF may benefit more from PWI.
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