Katelyn E Mooney, Derek B Archer, Aditi Sathe, Timothy J Hohman, Ose Kadiri, Melissa Lamar, Konstantinos Arfanakis, Lei Yu, Lisa L Barnes, Kacie D Deters
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Katelyn E MooneyUniversity of California Los Angeles, Neuroscience Interdepartmental Program (NSIDP), David Geffen School of Medicine Los Angeles California USA.ORCID https://orcid.org/0000-0002-8518-6937
Derek B ArcherVanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Nashville Tennessee USA.
Aditi SatheVanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Nashville Tennessee USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Nashville Tennessee USA.
Ose KadiriDepartment of Integrative Biology and Physiology University of California Los Angeles Los Angeles California USA.
Melissa LamarRush Alzheimer's Disease Center Rush University Medical Center Chicago USA.
Konstantinos ArfanakisRush Alzheimer's Disease Center Rush University Medical Center Chicago USA.
Lei YuRush Alzheimer's Disease Center Rush University Medical Center Chicago USA.
Lisa L BarnesRush Alzheimer's Disease Center Rush University Medical Center Chicago USA.
Kacie D DetersDepartment of Integrative Biology and Physiology University of California Los Angeles Los Angeles California USA.
Funding
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Risk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2M
Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
Genetic Drivers of Resilience to Alzheimer's DiseaseR01AG059716 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2018 to 2022
$4.4M
MRI markers of brain aging and risk factors for cognitive decline in older African AmericansR01AG056405 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2018 to 2023
$3.6M
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaU01NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2023 to 2025
$3.5M
In-vivo MRI-based prediction of TDP43 pathology in agingR01AG064233 · NIA · ILLINOIS INSTITUTE OF TECHNOLOGY · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2019 to 2023
$3.3M
UCSD Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Faculty Development ProgramR25NS117367 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Victoria B Risbrough, Joann Trejo · 2020 to 2026
$1.6M
The Impact of Social, Genetic and Neuroimaging Factors on Cognitive Functioning in the Black CommunityK01NS127947 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kacie Deters · 2023 to 2026
$859k
Genetic Contributors to White Matter Microstructure in Aging and Alzheimers DiseaseK01AG073584 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARCHER, DEREK B · 2021 to 2025
introductionWe assessed associations between apolipoprotein E Translocase of Outer Mitochondrial Membrane 40 (
methodsLinear regression models, stratified by
resultsBlack-ε4+-one-'523-S carriers had lower FW in the cingulum and inferior longitudinal fasciculus compared to Black-ε4+-no-'523-S carriers. Additionally, Black-ε4+-one-'523-S carriers had lower FW in the cingulum, uncinate, and fornix, and higher FA DISCUSSION: This supports prior work that '523-S is associated with abnormal aging in White-ε3/ε3 carriers, but is potentially risk-mitigating in Black-ε4+ carriers, while suggesting a differential effect by racialized background of Highlights: White matter microstructure (WMM) across limbic tracts important for cognition was measured by diffusion MRI.Black apolipoprotein E (APOE) ε4+ carriers with one copy of TOMM40-'523-S had normal aging WMM metrics across several tracts, including the cingulum bundle, uncinate fasciculus, fornix, and inferior longitudinal fasciculus.White APOE ε3/ε3 carriers with two copies of TOMM40-'523-S had abnormal aging WMM metrics in the cingulum bundle and inferior temporal gyrus.APOE associations with aging may differ in racialized groups due to TOMM40-'523-S copy number.
Indexed as
agingAlzheimer's disease (AD)APOEdiffusion magnetic resonance imaging (dMRI)free water corrected metricsgenetic risk factorslimbic system tractsMinority Aging Research StudyRush Memory and Aging ProjectTOMM40white matter microstructure (WMM)
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.