Evidence map›Paper›PMID 40201581›Full record

ArticleFrontiers in nutrition2025

Interaction between dietary selenium intake and age on severe headache or migraine in the United States: a population-based study.

Xinping Yu, Lanxiang Wu, Heqing Zheng, Wei Wu, Sheng Tian

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
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2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xinping Yu *Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Lanxiang Wu *Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Heqing Zheng *Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wei WuDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Sheng TianDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies have shown that an antioxidant diet is a protective factor against migraine. However, the association between selenium, an important antioxidant consumed from the diet, and migraine has received little attention. The aim of this study was to explore the relationship between dietary selenium intake with migraine, with particular interest in age differences. Methods: This study based on cross-sectional data from people who took part in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2004. The multiple logistic regression model was applied to examine the association between selenium intake and migraine, and subgroup analyses were performed. Non-linear associations were explored with restricted cubic spline (RCS) models. Results: The study included a total of 9,849 adults aged 20 years and older. Compared with individuals with lowest selenium intake Q1 (≤59.4 ug/day), the adjusted OR values for selenium intake and migraine in Q2 (59.41-82.70 ug/day), Q3 (82.71-106 ug/day), Q4 (106.01-143.16 ug/day), and Q5 (≥143.17 ug/day) were 0.82 (95% CI: 0.64-1.05), 0.99 (95% CI: 0.77-1.26), 0.74 (95% CI: 0.54-0.99), and 0.68 (95% CI: 0.48-0.97), respectively. Sensitivity analyses showed a robust association between them. Our findings also suggested an interaction between age and selenium intake ( Conclusion: A higher dietary selenium intake is significantly associated with a decreased prevalence of migraine, and age can modify the association between them. Therefore, the present study indicate that an appropriate intake of selenium-rich foods in adults aged 20-50 years may prevent migraines.

Indexed as

agedietary selenium intakeinteractive effectsmigraineNHANES

Identifiers

PMID40201581
PMCPMC11975585

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