Evidence map›Paper›PMID 40201450›Full record

ReviewNeurobiology of language (Cambridge, Mass.)2025

Stuttering: Our Current Knowledge, Research Opportunities, and Ways to Address Critical Gaps.

Soo-Eun Chang, Jennifer E Below, Ho Ming Chow, Frank H Guenther, Amanda M Hampton Wray, Eric S Jackson, Ludo Max, Nicole E Neef, Shahriar SheikhBahaei, Lana Shekim and 5 more

Abstract readReview
In one paragraph

Review in Neurobiology of language (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. A stuttering-associatedbioRxiv : the preprint server for biology · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Soo-Eun ChangDepartment of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0003-4448-9525
Jennifer E BelowThe Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-6372-6402
Ho Ming ChowDepartment of Communication Sciences and Disorders, University of Delaware, Newark, DE, USA.ORCID https://orcid.org/0000-0001-9333-4840
Frank H GuentherDepartments of Speech, Language, & Hearing Sciences and Biomedical Engineering, Boston University, Boston, MA, USA.ORCID https://orcid.org/0000-0003-1161-1555
Amanda M Hampton WrayDepartment of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-7049-8797
Eric S JacksonDepartment of Communicative Sciences and Disorders, New York University, New York, NY, USA.ORCID https://orcid.org/0000-0003-2896-0452
Ludo MaxDepartment of Speech & Hearing Sciences, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-3967-5545
Nicole E NeefDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Georg August University, Göttingen, Germany.ORCID https://orcid.org/0000-0003-2414-7595
Shahriar SheikhBahaeiNeuron-Glia Signaling and Circuits Unit, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-4119-9979
Lana ShekimNational Institute on Deafness and other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, MD, USA.
Seth E TichenorDepartment of Speech-Language Pathology, Duquesne University, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-9099-9684
Bridget WalshDepartment of Communicative Sciences and Disorders, Michigan State University, East Lansing, MI, USA.ORCID https://orcid.org/0000-0003-3526-7218
Kate E WatkinsDepartment of Experimental Psychology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-2621-482X
J Scott YarussDepartment of Communicative Sciences and Disorders, Michigan State University, East Lansing, MI, USA.ORCID https://orcid.org/0000-0003-1964-575X
Nan Bernstein RatnerDepartment of Hearing and Speech Sciences & Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD, USA.ORCID https://orcid.org/0000-0002-9947-0656

Funding

Sexual dimorphism of neural development underlying childhood stutteringR01DC011277 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Soo-Eun Chang · 2010 to 2026
$8.2M
Developmental Trajectories to Stuttering Persistence and RecoveryR01DC018000 · NIDCD · MICHIGAN STATE UNIVERSITY · PI WALSH, BRIDGET M · 2020 to 2025
$3.3M
Behavioral and neural characteristics of adaptive speech motor controlR01DC020707 · NIDCD · UNIVERSITY OF WASHINGTON · PI LUDO MAX · 2023 to 2026
$2.0M
Dynamic bidirectional sensorimotor interactions in stutteringR01DC017444 · NIDCD · UNIVERSITY OF WASHINGTON · PI MAX, LUDO · 2019 to 2023
$1.6M
NIDCD NIH HHS R01 DC011277NIDCD NIH HHS R01 DC017444NIDCD NIH HHS R01 DC018000NIDCD NIH HHS R01 DC020707
6 · The paper itself

Abstract

Our understanding of the neurobiological bases of stuttering remains limited, hampering development of effective treatments that are informed by basic science. Stuttering affects more than 5% of all preschool-age children and remains chronic in approximately 1% of adults worldwide. As a condition that affects a most fundamental human ability to engage in fluid and spontaneous verbal communication, stuttering can have substantial psychosocial, occupational, and educational impacts on those who are affected. This article summarizes invited talks and breakout sessions that were held in June 2023 as part of a 2-day workshop sponsored by the US National Institute on Deafness and Other Communication Disorders. The workshop encompassed topics including neurobiology, genetics, speech motor control, cognitive, social, and emotional impacts, and intervention. Updates on current research in these areas were summarized by each speaker, and critical gaps and priorities for future research were raised, and then discussed by participants. Research talks were followed by smaller, moderated breakout sessions intended to elicit diverse perspectives, including on the matter of defining therapeutic targets for stuttering. A major concern that emerged following participant discussion was whether priorities for treatment in older children and adults should focus on targeting core speech symptoms of stuttering, or on embracing effective communication regardless of whether the speaker exhibits overt stuttering. This article concludes with accumulated convergent points endorsed by most attendees on research and clinical priorities that may lead to breakthroughs with substantial potential to contribute to bettering the lives of those living with this complex speech disorder.

Indexed as

geneticsinterventionneurobiologyresearch prioritiesspeech disordertreatment

Identifiers

PMID40201450
PMCPMC11977836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.