Evidence map›Paper›PMID 40201438›Full record

ArticleFrontiers in microbiology2025

Effects of dietary fiber on the composition, function, and symbiotic interactions of intestinal microbiota in pre-weaned calves.

Wentao Lu, Xia Yi, Yuhan Ge, Xinyue Zhang, Kaidi Shen, Haohua Zhuang, Zhaoju Deng, Dengke Liu, Jie Cao, Chong Ma

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wentao LuCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Xia YiCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Yuhan GeCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Xinyue ZhangCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Kaidi ShenCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Haohua ZhuangCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhaoju DengCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Dengke LiuHebei Shounong Modern Agricultural Technology Co., LTD., Dingzhou, China.
Jie CaoCollege of Veterinary Medicine, China Agricultural University, Beijing, China.
Chong MaCollege of Veterinary Medicine, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dietary fiber plays a crucial role in maintaining gastrointestinal health. However, its protective effects on the intestinal health of calves remain to be fully elucidated. This study aimed to investigate the impact of dietary fiber supplementation on the intestinal microbiota of pre-weaned calves and its potential role in modulating microbial metabolic pathways. Methods: A randomized controlled trial was conducted, enrolling 135 calves that were randomly assigned into three groups: (1) inulin supplementation, (2) psyllium husk powder (PHP) supplementation, and (3) a control group receiving no dietary fiber. Fecal microbiota samples were collected from calves without diarrhea at five time points (0, 7, 14, 28, and 56 days of age). Metagenomic sequencing was performed to analyze microbial composition and functional pathways. Additionally, a differential analysis of carbohydrate-active enzymes (CAZymes) was performed to evaluate the effect of dietary fiber on carbohydrate metabolism enzyme activity within the intestinal microbiota. Results: Calves supplemented with dietary fiber exhibited a significant increase in the abundance of Discussion: The findings of this study highlight the beneficial effects of dietary fiber on calf intestinal microbiota, particularly in enhancing microbial diversity and enzymatic activity related to carbohydrate metabolism. The observed microbial symbiosis in PHP-fed calves suggests a potential role in maintaining intestinal homeostasis. These insights provide a theoretical foundation for optimizing dietary interventions to promote gut health in calves during the transition period. Further research is warranted to explore the mechanistic interactions between dietary fiber, gut microbiota, and host health outcomes.

Indexed as

Bifidobacteriumcalvesdietary fibergastrointestinal healthintestinal homeostasismicrobial interactionsPrevotella

Identifiers

PMID40201438
PMCPMC11975667

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.