Evidence map›Paper›PMID 40201425›Full record

ArticleISME communications2025

Food colorant brilliant blue causes persistent functional and structural changes in an in vitro simplified microbiota model system.

Victor Castañeda-Monsalve, Sven-Bastiaan Haange, Laura-Fabienne Fröhlich, Qiuguo Fu, Ulrike Rolle-Kampczyk, Martin von Bergen, Nico Jehmlich

Abstract read
In one paragraph

Article in ISME communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Victor Castañeda-MonsalveDepartment of Molecular Toxicology, Helmholtz Centre for Environmental Research - UFZ GmbH, 04318 Leipzig, Germany.
Sven-Bastiaan HaangeDepartment of Molecular Toxicology, Helmholtz Centre for Environmental Research - UFZ GmbH, 04318 Leipzig, Germany.
Laura-Fabienne FröhlichDepartment of Environmental Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ GmbH, 04318 Leipzig, Germany.
Qiuguo FuDepartment of Environmental Analytical Chemistry, Helmholtz Centre for Environmental Research - UFZ GmbH, 04318 Leipzig, Germany.
Ulrike Rolle-KampczykDepartment of Molecular Toxicology, Helmholtz Centre for Environmental Research - UFZ GmbH, 04318 Leipzig, Germany.
Martin von BergenDepartment of Molecular Toxicology, Helmholtz Centre for Environmental Research - UFZ GmbH, 04318 Leipzig, Germany.
Nico JehmlichDepartment of Molecular Toxicology, Helmholtz Centre for Environmental Research - UFZ GmbH, 04318 Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut microbiota plays a vital role in maintaining host health by acting as a barrier against pathogens, supporting the immune system, and metabolizing complex carbon sources into beneficial compounds such as short-chain fatty acids. Brilliant blue E-133 (BB), is a common food dye that is not absorbed or metabolized by the body, leading to substantial exposure of the gut microbiota. Despite this, its effects on the microbiota are not well-documented. In this study, we cultivated the Simplified Human Microbiota Model (SIHUMIx) in a three-stage in vitro approach (stabilization, exposure, and recovery). Using metaproteomic and metabolomic approaches, we observed significant shifts in microbial composition, including an increase in the relative abundance of

Indexed as

brilliant bluefood colorantshuman gut microbiotametabolomicsmetaproteomicsSIHUMIx

Identifiers

PMID40201425
PMCPMC11977461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.