Evidence map›Paper›PMID 40201414›Full record

ArticleJournal of the American College of Emergency Physicians open2025

Cardiac Arrest From Local Anesthetic Systemic Toxicity (LAST): A Rare Complication of Ultrasound-Guided Sternal Hematoma Block.

Kate G Radcliffe, Tessa Adler, Jordan Petersen, Kaitlen Howell, Arun Nagdev, David Martin

Abstract readCase Reports
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kate G RadcliffeSchool of Medicine, University of California, San Francisco, San Francisco, California, USA.
Tessa AdlerDepartment of Emergency Medicine, Highland Hospital - Alameda Health System, Oakland, California, USA.
Jordan PetersenDepartment of Emergency Medicine, Highland Hospital - Alameda Health System, Oakland, California, USA.
Kaitlen HowellDepartment of Emergency Medicine, Highland Hospital - Alameda Health System, Oakland, California, USA.
Arun NagdevDepartment of Emergency Medicine, Highland Hospital - Alameda Health System, Oakland, California, USA.
David MartinDepartment of Emergency Medicine, Highland Hospital - Alameda Health System, Oakland, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Local anesthetic systemic toxicity (LAST) is a rare but serious complication of ultrasound-guided nerve and hematoma blocks, affecting the cardiovascular and central nervous systems. Clinicians performing these procedures should be aware of the possibility of LAST, recognize the early signs and symptoms, and understand the current accepted treatment. We present a case of cardiovascular collapse caused by LAST following an ultrasound-guided sternal hematoma block and discuss potential systems-based improvements to enhance the management and prevention of this life-threatening emergency. Thoracic blocks may pose a higher risk of LAST because of the close proximity to the heart, and we recommend using lower doses of local anesthetic when performing these blocks.

Indexed as

nerve blockpainregional anesthesiasternal fractureultrasound

Identifiers

PMID40201414
PMCPMC11976237

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.