Evidence map›Paper›PMID 40201376›Full record

ArticleClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology2025

Effects of enzyme replacement therapy in sibling cases of hypophosphatasia of varying severities.

Junko Kanno, Tomohiro Nakagawa, Akinobu Miura, Hirohito Shima, Chisumi Sogi, Miki Kamimura, Ikuma Fujiwara, Kanako Tachikawa, Ryoko Hino, Toshimi Michigami and 1 more

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In one paragraph

Article in Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junko KannoDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tomohiro NakagawaDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Akinobu MiuraDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hirohito ShimaDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Chisumi SogiDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Miki KamimuraDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ikuma FujiwaraDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kanako TachikawaDepartment of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Japan.
Ryoko HinoDivision of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Toshimi MichigamiDepartment of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Japan.
Atsuo KikuchiDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypophosphatasia (HPP) is a hereditary disorder characterized by impaired bone mineralization caused by decreased tissue-nonspecific alkaline phosphatase (TNSALP) activity. Specifically, HPP is caused by a loss-of-function variant in the

Indexed as

enzyme replacement therapyhypophosphatasiarecombinant alkaline phosphataseTNSALP

Identifiers

PMID40201376
PMCPMC11972865

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.