ArticleFrontiers in public health2025
Sex differences in acute respiratory tract infections-multi-year analysis based on data from a large tertiary care medical center in Israel.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Global, regional, and national burden of upper respiratory infections in adolescents and young adults: an analysis of the Global Burden of Disease Study 2021.Journal of thoracic disease · 2026Article
- Comparative epidemiology of six respiratory pathogens among children aged 28 days to 14 years with acute respiratory infections in coastal Xiamen and inland Linxia, China: a multicenter retrospective study.Frontiers in public health · 2026Article
- Epidemiology of respiratory infectious diseases after the relaxation of COVID-19 policies: a retrospective study in Xiamen, China.Frontiers in public health · 2026Article
- Presence of Dolosigranulum pigrum in the nasopharynx and its relationship with respiratory health status in paediatric population.PloS one · 2026Article
- Epidemiology ofFrontiers in public health · 2026Article
- Pre-COVID-19 epidemiology of community respiratory viruses at a single US center reveals sex differences in influenza A and a higher ICU incidence of human metapneumovirus in the elderly population.BMC infectious diseases · 2025Article
- Epidemiologic characteristics of immunoglobulin M antibodies in lower respiratory tract infection pathogens of children: association with severe pneumonia in Chengdu city from 2019 to 2023.American journal of translational research · 2025Article
- Prevalence of six respiratory pathogens among children in Chengdu, China: a multiplex PCR-based detection study.Frontiers in cellular and infection microbiology · 2025Article
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Abstract
Introduction: Acute respiratory tract infections impose a considerable burden on the health services. The development of improved prevention and treatment measures requires a better understanding of the mechanisms of infection. Since sex has been shown to be an important biological variable in the immune response to infections, we aimed to assess sex differences in the incidence rates of respiratory infections. Materials and methods: We obtained data on cases hospitalized with diagnosed respiratory tract infections by sex and age group over a period of 11 years (2012-2022) from the Sheba Medical Center (SMC), the largest tertiary care medical center in Israel. Nasopharyngeal samples collected from the patients with symptoms of a respiratory tract infection were examined for adenovirus, influenza, rhinovirus, parainfluenza-3, human metapneumovirus (hMPV) and respiratory syncitial virus (RSV) in the Central Virology Laboratory and Viral RNA/DNA was extracted and tested using a real-time reverse transcription-PCR (rRT-PCR) assay. We calculated annual male to female incidence rate ratios (IRRs) which were combined over the period of the study using meta-analysis methodology. Results: There was a male excess in infection rates for all viruses, particularly in the youngest age groups of <0 and 1-4 years. Our analyses revealed that the influenza incidence rates were 42 and 28% higher in males in infants and toddlers. The male dominance was similar for adenovirus with 33 and 38% in infancy and age group 1-4. For RSV, the male to female IRR was higher at ages <1 and 1-4 (22 and 21% respectively). Males were more likely to be positive for rhinovirus in infancy and toddlers, by 40 and 25%, respectively. Conclusion: There is evidence of an excess incidence of respiratory diseases in males. The mechanism is unclear. Other than behavioral factors, there is a need to study the role of sex hormones and genetic factors.
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