ArticleFrontiers in oncology2025
Advantages of time-dependent diffusion MRI for quantitative microstructural mapping in breast tumors.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Feasibility of predicting breast cancer Ki-67 expression using histogram features derived from time-dependent diffusion magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- The value of time-dependent diffusion MRI in nasopharyngeal carcinoma: correlation with prognostic factors.European radiology · 2026Article
- A Novel, Promising Technique for Metastatic Lymph Node Detection in Uterine Cervical Cancer.Radiology. Imaging cancer · 2026Article
- Integrating time-dependent diffusion MRI and intravoxel incoherent motion for predicting NPI and molecular subtypes in breast cancer.BMC medical imaging · 2026Article
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11 authors.
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Abstract
Objectives: Time-dependent diffusion MRI (TD-MRI) can measure tumor tissue microstructure, but its effectiveness in differentiating benign from malignant breast tumors is unclear. This study aims to investigate the diagnostic value of TD-MRI microstructural features for distinguishing between benign and malignant breast tumors. Methods: This prospective study included 44 patients with malignant breast tumors and 28 with benign tumors. All subjects underwent the IMPULSED protocol on a 3.0-T MRI scanner. Imaging data were analyzed using least squares fitting in MATLAB, yielding Dex (extracellular diffusivity), Vin (intracellular volume fraction), Dmean (cell diameter), Vin/Dmean, and ADC values. The molecular subtypes of breast cancer are classified based on immunohistochemistry (IHC) results. Results: Malignant tumors exhibited significantly lower Dmean (17.37 ± 2.74 µm Conclusion: TD-MRI microstructure mapping effectively differentiates benign from malignant breast tumors, highlighting its potential to improve diagnostic accuracy for lesions.
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