Evidence map›Paper›PMID 40201185›Full record

ArticleBJR artificial intelligence2025

Artificial intelligence and consistency in patient care: a large-scale longitudinal study of mammographic density assessment.

Susan O Holley, Daniel Cardoza, Thomas P Matthews, Elisha E Tibatemwa, Rodrigo Morales Hoil, Adetunji T Toriola, Aimilia Gastounioti

Abstract read
In one paragraph

Article in BJR artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Susan O HolleyOnsite Women's Health, Nashville, TN 37203, United States.
Daniel CardozaWhiterabbit.ai, Redwood City, CA 94065, United States.
Thomas P MatthewsWhiterabbit.ai, Redwood City, CA 94065, United States.
Elisha E TibatemwaMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.
Rodrigo Morales HoilWhiterabbit.ai, Redwood City, CA 94065, United States.ORCID https://orcid.org/0000-0002-0573-8587
Adetunji T ToriolaDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, United States.ORCID https://orcid.org/0000-0003-1079-2606
Aimilia GastouniotiMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States.ORCID https://orcid.org/0000-0002-3359-7195

Funding

Advancing breast cancer risk assessment with digital breast tomosynthesisR01CA286120 · NCI · WASHINGTON UNIVERSITY · PI Aimilia Gastounioti · 2024 to 2026
$3.1M
NCI NIH HHS R01 CA286120
6 · The paper itself

Abstract

Objectives: To assess whether use of an artificial intelligence (AI) model for mammography could result in more longitudinally consistent breast density assessments compared with interpreting radiologists. Methods: The AI model was evaluated retrospectively on a large mammography dataset including 50 sites across the United States from an outpatient radiology practice. Examinations were acquired on Hologic imaging systems between 2016 and 2021 and were interpreted by 39 radiologists (36% fellowship trained; years of experience: 2-37 years). Longitudinal patterns in 4-category breast density and binary breast density (non-dense vs. dense) were characterized for all women with at least 3 examinations (61 177 women; 214 158 examinations) as constant, descending, ascending, or bi-directional. Differences in longitudinal density patterns were assessed using paired proportion hypothesis testing. Results: The AI model produced more constant ( Conclusions: AI produces more longitudinally consistent breast density assessments compared with interpreting radiologists. Advances in knowledge: Our results extend the advantages of AI in breast density evaluation beyond automation and reproducibility, showing a potential path to improved longitudinal consistency and more consistent downstream care for screened women.

Indexed as

artificial intelligencebreast cancer screeningbreast densitylongitudinal analysismammography

Identifiers

PMID40201185
PMCPMC11974406

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.