Evidence map›Paper›PMID 40201151›Full record

ArticleInternational journal of nanomedicine2025

Internal-External Homologous Drug-Loaded Exosome-Like Nanovesicles Released from Semi-IPN Hydrogel Enhancing Wound Healing of Chemoradiotherapy-Induced Oral Mucositis.

Xiangjuan Wei, Mengyuan Wang, Xiaocong Dong, Yichen He, Wenbin Nan, Shenglu Ji, Mengyuan Zhao, Haodang Chang, Hongliang Wei, Dan Ding and 1 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiangjuan Wei *Clinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Mengyuan Wang *Clinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Xiaocong DongClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Yichen HeClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Wenbin NanClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.ORCID 0000-0003-1750-2392
Shenglu JiClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Mengyuan ZhaoClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Haodang ChangClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.
Hongliang WeiSchool of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan, People's Republic of China.ORCID 0000-0001-7285-9285
Dan DingKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, People's Republic of China.
Hongli ChenClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.ORCID 0000-0002-7975-2509

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral mucositis (OM) is a common acute side effect among patients undergoing chemotherapy and/or radiotherapy, with complex pathogenesis and limited current treatment efficacy. Methods: We fabricated internally-externally homologous drug-loaded exosome-like nanovesicles (ORI/ENs) derived from Results: ENs were extracted and purified from Conclusion: The hydrogel composite incorporating internally-externally homologous drug-loaded ENs offers the potential to provide targeted therapy, improve bioavailability, and promote efficient healing of the OM.

Indexed as

ChemoradiotherapyDiterpenes, KauraneExosomesHydrogelsStomatitisWound HealingAnimalsAnti-Bacterial AgentsCell LineDrug Delivery SystemsDrug LiberationHumansIsodonMaleMiceNanoparticlesAnti-Bacterial AgentsDiterpenes, KauraneHydrogelsoridoninchemoradiotherapy-induced oral mucositisexosome-like nanovesicleshydrogelNLRP3oridonin

Identifiers

PMID40201151
PMCPMC11977572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.