Evidence map›Paper›PMID 40201128›Full record

ArticleiScience2025

Elastic properties of leukemic cells linked to maturation stage and integrin activation.

Ceri J Richards, Albertus T J Wierenga, Annet Z Brouwers-Vos, Emmanouil Kyrloglou, Laura S Dillingh, Patty P M F A Mulder, Georgios Palasantzas, Jan Jacob Schuringa, Wouter H Roos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ceri J RichardsMoleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, 9747 AG Groningen, the Netherlands.
Albertus T J WierengaDepartment of Experimental Hematology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
Annet Z Brouwers-VosDepartment of Experimental Hematology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
Emmanouil KyrloglouDepartment of Experimental Hematology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
Laura S DillinghMoleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, 9747 AG Groningen, the Netherlands.
Patty P M F A MulderPharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, the Netherlands.
Georgios PalasantzasNanostructure Materials and Interfaces, Zernike Institute for Advanced Materials, University of Groningen, 9747 AG Groningen, the Netherlands.
Jan Jacob SchuringaDepartment of Experimental Hematology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
Wouter H RoosMoleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, 9747 AG Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) remains challenging to cure. In addition to mutations that alter cell functioning, biophysical properties are modulated by external cues. In particular, membrane proteins that interact with the bone marrow niche can induce cellular changes. Here, we develop an atomic force microscopy (AFM) approach to measure non-adherent AML cell mechanical properties. The Young's modulus of the AML cell line, THP-1, increased in response to retronectin, whereas knock-out of the adhesion protein

Indexed as

BiomechanicsHealth sciencesNatural sciences

Identifiers

PMID40201128
PMCPMC11978321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.