ArticleiScience2025
Spatiotemporal proteomic and transcriptomic landscape of DAT+ dopaminergic neurons development and function.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Metal-Free Electrochemical Dopamine Sensing Using a g-CBiosensors · 2026Article
- Statistical Methods for Multi-Omics Analysis in Neurodevelopmental Disorders: From High Dimensionality to Mechanistic Insight.Biomolecules · 2025Review
- Proteomic insights into the biology of dopaminergic neurons.Frontiers in molecular neuroscience · 2025Review
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Authors and funding
6 authors.
Funding
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Abstract
Dopaminergic (DA) neurons expressing the dopamine transporter (DAT) play vital roles in physiology and the regulation of mental and neurological disorders. This study investigates spatiotemporal proteomic and transcriptomic changes in DAT+ DA neurons from key brain regions-the nucleus accumbens (NAc), substantia nigra (SNc), and ventral tegmental area (VTA)-at postnatal milestones: day 7 (P7), day 30 (P30), and day 60 (P60). Using advanced multi-omics techniques, including ultrasensitive trace sample proteomics and SMART-seq2, we reveal distinct molecular profiles within DA neuron populations, reflecting their developmental progression and functional roles. Immunofluorescence mapping validates these findings and underscores the dynamic molecular architecture of DA neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.