Evidence map›Paper›PMID 40201124›Full record

ArticleiScience2025

Efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes: A systematic review and meta-analysis.

Jingru Zhuang, Ying Ren, Minmin Chen, Minghui Yue, Changyong Yuan, Rongquan Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingru ZhuangSchool of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Ying RenSchool of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Minmin ChenSchool of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Minghui YueSchool of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Changyong YuanSchool of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Rongquan DuanSchool of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, and Web of Science were comprehensively searched until 4 December 2024, and 10 randomized controlled trials (RCTs) were included. The results indicated that, compared to the control group, localized sustained-release drugs significantly reduced probing depth (PD) (SMD = -0.77, 95% confidence interval [CI] (-1.37, -0.16)) but did not reduce clinical attachment loss (CAL) (SMD = -0.18, 95% CI (-0.60, 0.23)), sites with glycated hemoglobin (HbA1c) (SMD = 0.03, 95% CI (-0.38, 0.43)), plaque index (SMD = -0.37, 95% CI (-0.80, 0.06)), sites with bleeding on probing (BOP) (SMD = -0.26, 95% CI (-0.68, 0.16)), and gingival index (SMD = 0.07, 95% CI (-0.30, 0.44)). Subgroup analysis by different drugs elicited that, compared to the control treatment, chlorhexidine was effective in reducing BOP% (SMD = -0.55, 95% CI (-0.90, -0.19)). Our meta-analysis finds that the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes is limited.

Indexed as

DentistryDrugsHealth sciencesMedical specialtyMedical substanceMedicine

Identifiers

PMID40201124
PMCPMC11978340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.