ArticleFrontiers in neurology2025
Relationship between cognitive dysfunction and urinary 8-OHdG levels in children with obstructive sleep apnea.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advancements in pediatric obstructive sleep apnea: cognitive implications and the role of AI in precision medicine.Frontiers in medicine · 2025Pooled it
- Role of Free Radicals in the Pathophysiology of OSA: A Narrative Review of a Double-Edged Sword.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obstructive sleep apnea (OSA) is a condition characterized by partial or complete obstruction of the upper respiratory tract during sleep, which can result in neurocognitive deficits and cognitive dysfunction in children. Oxidative stress may play a significant role in OSA-related disorders, with 8-hydroxy-2'-deoxyguanosine (8-OHdG) serving as a primary marker of oxidative DNA damage for assessing oxidative stress levels. This study aims to investigate the relationship between urinary 8-OHdG levels in children with OSA and cognitive dysfunction. Methods: The study included children with habitual snoring from April 2023 to June 2024 at the Children's Hospital of Soochow University. All participants completed the PedsQL questionnaire and underwent polysomnography (PSG) assessment and urine collection for 8-OHdG analysis. Results: In total, 99 children with OSA and 35 children with non-OSA were included. The urinary 8-OHdG levels were higher in the OSA group (240.94 ± 11.51 pg./mL) than in the non-OSA group (230.73 ± 13.82 pg./mL) ( Conclusion: Urinary 8-OHdG may serve as a non-invasive, objective biomarker for assessing cognitive dysfunctions in children with OSA.
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